Pentothal
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Pentothal
Please Note: This Brand Name drug is no longer available in the US.(Generic versions may still be available.)
SIDE EFFECTS
Pentothal (thiopental sodium)
Adverse reactions include respiratory depression, myocardial depression, cardiac arrhythmias, prolonged somnolence and recovery, sneezing, coughing, bronchospasm, laryngospasm and shivering. Anaphylactic and anaphylactoid reactions to Pentothal (thiopental sodium) (Thiopental Sodium for Injection, USP) have been reported. Symptoms, e.g., urticaria, bronchospasm, vasodilation and edema should be managed by conventional means.
Rarely, immune hemolytic anemia with renal failure and radial nerve palsy have been reported.
DRUG ABUSE AND DEPENDENCE
WARNING: MAY BE HABIT FORMING.
Thiopental sodium is classified as a Schedule III controlled substance.
Diluents in Pentothal (thiopental sodium) ® Kits
Ready-To-Mix Syringes and Vials(For preparing solutions of Thiopental Sodium for Injection, USP)
Reactions which may occur because of the diluents, technique of preparation or mixing, or administration of reconstituted solutions of Pentothal (thiopental sodium) include febrile response or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation.
If an adverse reaction does occur, discontinue the injection, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of unused solution (or the used container or syringe) for examination if deemed necessary.
DRUG ABUSE AND DEPENDENCE
None known.
Read the Pentothal (thiopental sodium) Side Effects Center for a complete guide to possible side effects »
DRUG INTERACTIONS
The following drug interactions have been reported with thiopental.
| Drug | Effect |
| Probenecid | Prolonged action of thiopental |
| Diazoxide | Hypotension |
| Zimelidine | Thiopental antagonism |
| Opioid analgesics | Decreased antinociceptive action |
| Aminophylline | Thiopental antagonism |
| Midazolam | Synergism |
Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.
Additional Pentothal Information
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