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Pentothal

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Pentothal

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Pentothal

SIDE EFFECTS

Pentothal (thiopental sodium)

Adverse reactions include respiratory depression, myocardial depression, cardiac arrhythmias, prolonged somnolence and recovery, sneezing, coughing, bronchospasm, laryngospasm and shivering. Anaphylactic and anaphylactoid reactions to Pentothal (thiopental sodium) (Thiopental Sodium for Injection, USP) have been reported. Symptoms, e.g., urticaria, bronchospasm, vasodilation and edema should be managed by conventional means.

Rarely, immune hemolytic anemia with renal failure and radial nerve palsy have been reported.

DRUG ABUSE AND DEPENDENCE

WARNING: MAY BE HABIT FORMING.

Thiopental sodium is classified as a Schedule III controlled substance.

Diluents in Pentothal (thiopental sodium) ® Kits

Ready-To-Mix Syringes and Vials
(For preparing solutions of Thiopental Sodium for Injection, USP)

Reactions which may occur because of the diluents, technique of preparation or mixing, or administration of reconstituted solutions of Pentothal (thiopental sodium) include febrile response or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation.

If an adverse reaction does occur, discontinue the injection, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of unused solution (or the used container or syringe) for examination if deemed necessary.

DRUG ABUSE AND DEPENDENCE

None known.

Read the Pentothal (thiopental sodium) Side Effects Center for a complete guide to possible side effects

DRUG INTERACTIONS

The following drug interactions have been reported with thiopental.

Drug Effect
   Probenecid    Prolonged action of thiopental 
   Diazoxide    Hypotension
   Zimelidine    Thiopental antagonism 
   Opioid analgesics    Decreased antinociceptive action
   Aminophylline     Thiopental antagonism
   Midazolam    Synergism

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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