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Pentothal

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Pentothal

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Pentothal

WARNINGS

Pentothal (thiopental sodium)

KEEP RESUSCITATIVE AND ENDOTRACHEAL INTUBATION EQUIPMENT AND OXYGEN READILY AVAILABLE. MAINTAIN PATENCY OF THE AIRWAY AT ALL TIMES.

This drug should be administered only by persons qualified in the use of intravenous anesthetics.

Avoid extravasation or intra-arterial injection.

WARNING: MAY BE HABIT FORMING.

Diluents in Pentothal (thiopental sodium) ® Kits

Ready-To-Mix Syringes and Vials
(For preparing solutions of Thiopental Sodium for Injection, USP)

Intravenous administration of Sterile Water for Injection, USP without a solute may result in hemolysis.

Use aseptic technique for preparing Pentothal (thiopental sodium) solutions when using Pentothal (thiopental sodium) Kits, Syringes or Vials and during withdrawal from reconstituted single or multiple-use containers.

Administer only clear reconstituted solutions.

Use within 24 hours after reconstitution. Discard unused portions.

PRECAUTIONS

Pentothal (thiopental sodium)

Observe aseptic precautions at all times in preparation and handling of Pentothal (Thiopental Sodium for Injection, USP) solutions.

If used in conditions involving relative contraindications, reduce dosage and administer slowly.

Care should be taken in administering the drug to patients with advanced cardiac disease, increased intracranial pressure, ophthalmoplegia plus, asthma, myasthenia gravis and endocrine insufficiency (pituitary, thyroid, adrenal, pancreas).

Drug Interactions

See DRUG INTERACTIONS section.

Nursing Mothers

Thiopental sodium readily crosses the placental barrier and small amounts may appear in the milk of nursing mothers following administration of large doses.

Pregnancy

Pregnancy Category C. Animal reproduction studies have not been conducted with Pentothal (thiopental sodium) . It is also not known whether Pentothal (thiopental sodium) can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Pentothal (thiopental sodium) should be given to a pregnant woman only if clearly needed.

Diluents in Pentothal (thiopental sodium) ® Kits

Ready-To-Mix Syringes and Vials
(For preparing solutions of Thiopental Sodium for Injection, USP)

Do not use unless solution is clear and container is undamaged.

Inspect reconstituted (mixed) solutions of Pentothal (Thiopental Sodium for Injection, USP) for clarity and freedom from precipitation or discoloration prior to administration. Use reconstituted solution only if it is clear, free from precipitate and not discolored.

Use Transfer Label in each Pentothal (thiopental sodium) Kit and affix to container of reconstituted solution to show concentration and time of preparation.

Pregnancy

Pregnancy Category C. Animal reproduction studies have not been conducted with sterile water for injection or sodium chloride injection. It is also not known whether sterile water or sodium chloride injection containing additives can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Sterile water for injection or sodium chloride injection with additives should be given to a pregnant woman only if clearly needed.

Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.

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