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Percodan Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking aspirin and oxycodone (Percodan)?

Aspirin should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Aspirin can cause a serious and sometimes fatal condition called Reye's syndrome in children.

You should not use this medication if you are allergic to aspirin or oxycodone, or if you have:

  • a recent history of stomach or intestinal bleeding;
  • a bleeding or blood clotting disorder such as hemophilia;
  • if you are taking a blood thinner such as warfarin (Coumadin, Jantoven); or
  • an allergy to an NSAID (non-steroidal anti-inflammatory drug) such as Advil, Motrin, Aleve, Celecoxib, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others.

Do not use aspirin and oxycodone if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

To make sure you can safely take aspirin and oxycodone, tell your doctor if you have any of these other conditions:

  • stomach or intestinal disorder, history of stomach ulcer or bleeding;
  • severe constipation, a blockage in your stomach or intestines;
  • liver or kidney disease;
  • allergies, nasal polyps, asthma or other breathing disorders;
  • a heart rhythm disorder, low blood pressure;
  • enlarged prostate, urination problems;
  • underactive thyroid;
  • gallbladder disease;
  • seizures, or a history of head injury or brain tumor;
  • Addison's disease or other adrenal gland disorder;
  • curvature of the spine;
  • mental illness, a history of drug or alcohol addiction; or
  • if you have been sick with diarrhea.

Oxycodone may be habit forming and should be used only by the person for whom it was prescribed. Never share this medication with another person, especially someone with a history of drug abuse or addiction.

FDA pregnancy category D. This medication can cause harm to an unborn baby, and breathing problems or addiction/withdrawal symptoms in a newborn. Taking aspirin during late pregnancy may cause bleeding in the mother or the baby during delivery. Do not take aspirin and oxycodone during pregnancy unless your doctor has told you to. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Aspirin and oxycodone can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take aspirin and oxycodone (Percodan)?

Take exactly as prescribed. Never take aspirin and oxycodone in larger amounts, or for longer than recommended by your doctor. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Aspirin and oxycodone may be taken with food if it upsets your stomach.

If you need surgery, tell the surgeon ahead of time that you are using aspirin and oxycodone.

Do not stop using aspirin and oxycodone suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using aspirin and oxycodone.

Store at room temperature away from moisture, heat, and light. After you have stopped using this medication, flush any unused pills down the toilet.

Keep track of the amount of medicine used from each new bottle. Oxycodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Always check your bottle to make sure you have received the correct pills (same brand and type) of medicine prescribed by your doctor. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy.

Side Effects Centers

Percodan - User Reviews

Percodan User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Percodan sorted by most helpful. Patient Discussions FAQs

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Chronic Pain/Back Pain

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