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Percodan

Last reviewed on RxList: 8/12/2010
Percodan Patient Information Including Side Effects

Brand Names: Endodan, Percodan, Roxiprin

Generic Name: aspirin and oxycodone (Pronunciation: AS pir in and ox i KOE done)

What is aspirin and oxycodone (Percodan)?

Aspirin is in a group of drugs called salicylates (sa-LIS-il-ates). It works by reducing substances in the body that cause pain, fever, and inflammation.

Oxycodone is an opioid pain medication. An opioid is sometimes called a narcotic.

The combination of aspirin and oxycodone is used to relieve moderate to severe pain.

Aspirin and oxycodone may also be used for purposes not listed in this medication guide.

What are the possible side effects of aspirin and oxycodone (Percodan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • severe stomach pain or constipation, vomiting;
  • black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • weak or shallow breathing, fast or slow heartbeats;
  • confusion, hallucinations, feeling like you might pass out;
  • easy bruising or bleeding;
  • seizures; or
  • decreased hearing, ringing in your ears.

Less serious side effects may include:

  • headache, dizziness, drowsiness;
  • constipation, heartburn, upset stomach, bloating, gas, diarrhea; or
  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the Percodan (aspirin and oxycodone hydrochloride) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about aspirin and oxycodone (Percodan)?

Aspirin should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Aspirin can cause a serious and sometimes fatal condition called Reye's syndrome in children.

You should not take aspirin and oxycodone if you have a bleeding disorder, a recent history of stomach or intestinal bleeding, if you take a blood thinner, or if you are allergic to aspirin, oxycodone, or an NSAID (non-steroidal anti-inflammatory drug) such as Advil, Motrin, Aleve, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others.

Do not use aspirin and oxycodone if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Oxycodone may be habit-forming and should be used only by the person for whom it was prescribed. Keep the medication in a secure place where others cannot get to it.

Ask a doctor or pharmacist before using any other over-the-counter cold, allergy, or pain medicine. Aspirin is contained in many combination medicines. Taking certain products together can cause you to get too much aspirin. Check the label to see if a medicine contains aspirin.

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Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Percodan Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking aspirin and oxycodone (Percodan)?

Aspirin should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Aspirin can cause a serious and sometimes fatal condition called Reye's syndrome in children.

You should not use this medication if you are allergic to aspirin or oxycodone, or if you have:

  • a recent history of stomach or intestinal bleeding;
  • a bleeding or blood clotting disorder such as hemophilia;
  • if you are taking a blood thinner such as warfarin (Coumadin, Jantoven); or
  • an allergy to an NSAID (non-steroidal anti-inflammatory drug) such as Advil, Motrin, Aleve, Celecoxib, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others.

Do not use aspirin and oxycodone if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

To make sure you can safely take aspirin and oxycodone, tell your doctor if you have any of these other conditions:

  • stomach or intestinal disorder, history of stomach ulcer or bleeding;
  • severe constipation, a blockage in your stomach or intestines;
  • liver or kidney disease;
  • allergies, nasal polyps, asthma or other breathing disorders;
  • a heart rhythm disorder, low blood pressure;
  • enlarged prostate, urination problems;
  • underactive thyroid;
  • gallbladder disease;
  • seizures, or a history of head injury or brain tumor;
  • Addison's disease or other adrenal gland disorder;
  • curvature of the spine;
  • mental illness, a history of drug or alcohol addiction; or
  • if you have been sick with diarrhea.

Oxycodone may be habit forming and should be used only by the person for whom it was prescribed. Never share this medication with another person, especially someone with a history of drug abuse or addiction.

FDA pregnancy category D. This medication can cause harm to an unborn baby, and breathing problems or addiction/withdrawal symptoms in a newborn. Taking aspirin during late pregnancy may cause bleeding in the mother or the baby during delivery. Do not take aspirin and oxycodone during pregnancy unless your doctor has told you to. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Aspirin and oxycodone can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take aspirin and oxycodone (Percodan)?

Take exactly as prescribed. Never take aspirin and oxycodone in larger amounts, or for longer than recommended by your doctor. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Aspirin and oxycodone may be taken with food if it upsets your stomach.

If you need surgery, tell the surgeon ahead of time that you are using aspirin and oxycodone.

Do not stop using aspirin and oxycodone suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using aspirin and oxycodone.

Store at room temperature away from moisture, heat, and light. After you have stopped using this medication, flush any unused pills down the toilet.

Keep track of the amount of medicine used from each new bottle. Oxycodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Always check your bottle to make sure you have received the correct pills (same brand and type) of medicine prescribed by your doctor. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy.

Percodan Patient Information including If I Miss a Dose

What happens if I miss a dose (Percodan)?

Since aspirin and oxycodone is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose (Percodan)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of aspirin and oxycodone can be fatal.

Overdose symptoms may include extreme drowsiness, pinpoint pupils, nausea, vomiting, diarrhea, confusion, ringing in your ears, cold or clammy skin, muscle weakness, fainting, weak pulse, slow heart rate, coma, blue lips, shallow breathing, or no breathing.

What should I avoid while taking aspirin and oxycodone (Percodan)?

This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how aspirin and oxycodone will affect you.

Ask a doctor or pharmacist before using any other over-the-counter cold, allergy, or pain medicine. Aspirin is contained in many combination medicines. Taking certain products together can cause you to get too much aspirin. Check the label to see if a medicine contains aspirin.

Avoid taking acetaminophen (Tylenol) or an NSAID while you are taking aspirin and oxycodone, unless your doctor tells you to. NSAIDs include ibuprofen (Advil, Motrin), ketorolac (Toradol), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others.

Avoid drinking alcohol. It may increase your risk of stomach bleeding while taking aspirin.

What other drugs will affect aspirin and oxycodone (Percodan)?

Ask your doctor before using an antidepressant such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Rapiflux, Sarafem, Selfemra, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil, Pexeva), sertraline (Zoloft), trazodone (Desyrel, Oleptro), or vilazodone (Viibryd). Taking any of these medicines with aspirin may cause you to bruise or bleed easily.

Before using this medication, tell your doctor if you regularly use other medicines that make you sleepy or could slow your breathing (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by aspirin and oxycodone.

Many drugs can interact with aspirin and oxycodone. Below is just a partial list. Tell your doctor if you are using:

  • bupropion (Wellbutrin, Zyban);
  • deferasirox (Exjade);
  • leflunomide (Arava);
  • methotrexate (Rheumatrex, Trexall);
  • sirolimus (Rapamune) or tacrolimus (Prograf);
  • tenofovir (Viread, Atripla, Complera, Truvada);
  • antiviral medicines such as adefovir (Hepsera) or cidofovir (Vistide);
  • aspirin or other salicylates including Kaopectate, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and others;
  • bowel cleansing preparations (Half Lytely, Fleet Prep Kit, Evac-Q-Kwik, GoLytely, Supraprep, and others);
  • glaucoma medication such as acetazolamide (Diamox) or methazolamide (Glauctabs, Neptazane); or
  • medication used to prevent blood clots, such as dalteparin (Fragmin), enoxaparin (Lovenox), fondaparinux (Arixtra), tinzaparin (Innohep), and others.

This list is not complete and other drugs may interact with aspirin and oxycodone. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about aspirin and oxycodone.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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