Peridex Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Peridex (chlorhexidine gluconate 0.12%) Oral Rinse is an antimicrobial rinse used along with tooth brushing and flossing as part of a program to treat gingivitis. This medication is available in generic form. Common side effects include tooth/tongue staining, increased tartar, mouth/throat irritation, and changes in taste.
The usual dosage of Peridex is 15ml undiluted (marked in cap). The recommended use is twice daily oral rinsing for 30 seconds, morning and evening after tooth brushing. Peridex may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, Peridex should be used only if prescribed. It is unknown if this drug is passes into breast milk. Consult your doctor before breastfeeding.
Our Peridex (chlorhexidine gluconate 0.12%) Oral Rinse Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Peridex FDA Prescribing Information: Side Effects
The most common side effects associated with chlorhexidine gluconate oral rinses are: 1) an increase in staining of teeth and other oral surfaces; 2) an increase in calculus formation; and 3) an alteration in taste perception, see WARNINGS and PRECAUTIONS. Oral irritation and local allergy-type symptoms have been spontaneously reported as side effects associated with use of chlorhexidine gluconate rinse. The following oral mucosal side effects were reported during placebo-controlled adult clinical trials: aphthous ulcer, grossly obvious gingivitis, trauma, ulceration, erythema, desquamation, coated tongue, keratinization, geographic tongue, mucocele, and short frenum. Each occurred at a frequency of less than 1.0%. Among post marketing reports, the most frequently reported oral mucosal symptoms associated with Peridex are stomatitis, gingivitis, glossitis, ulcer, dry mouth, hypesthesia, glossal edema, and paresthesia. Minor irritation and superficial desquamation of the oral mucosa have been noted in patients using Peridex. There have been cases of parotid gland swelling and inflammation of the salivary glands (sialadenitis) reported in patients using Peridex.
Read the entire FDA prescribing information for Peridex (Chlorhexidine Gluconate 0.12% Oral Rinse) »
Additional Peridex Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
WebMD Oral Health
Get tips for a healthy mouth.