Adverse Reactions in Clinical Trials of a bioequivalent form of doxycycline hyclate capsules: In clinical trials of adult patients with periodontal disease 213 patients received 20 mg BID over a 9 - 12 month period. The most frequent adverse reactions occurring in studies involving treatment with a bioequivalent form of doxycycline hyclate capsules or placebo are listed below:
Incidence (%) of Adverse Reactions in Clinical Trials of
Doxycycline Hyclate Capsules, 20mg (Bioequivalent to Doxycycline Hyclate Tablets,
20mg) vs. Placebo
|Adverse Reaction||Doxycycline Hyclate
Capsules 20 mg BID
|Headache||55 (26%)||56 (26%)|
|Common Cold||47 (22%)||46 (21%)|
|Flu Symptoms||24 (11%)||40 (19%)|
|Tooth Ache||14 (7%)||28 (13%)|
|Periodontal Abscess||8 (4%)||21 (10%)|
|Tooth Disorder||13 (6%)||19 (9%)|
|Nausea||17 (8%)||12 (6%)|
|Sinusitis||7 (3%)||18 (8%)|
|Injury||11 (5%)||18 (8%)|
|Dyspepsia||13 (6%)||5 (2%)|
|Sore Throat||11 (5%)||13 (6%)|
|Joint Pain||12 (6%)||8 (4%)|
|Diarrhea||12 (6%)||8 (4%)|
|Sinus Congestion||11 (5%)||11 (5%)|
|Coughing||9 (4%)||11 (5%)|
|Sinus Headache||8 (4%)||8 (4%)|
|Rash||8 (4%)||6 (3%)|
|Back Pain||7 (3%)||8 (4%)|
|Back Ache||4 (2%)||9 (4%)|
|Menstrual Cramp||9 (4%)||5 (2%)|
|Acid Indigestion||8 (4%)||7 (3%)|
|Pain||8 (4%)||5 (2%)|
|Infection||4 (2%)||6 (3%)|
|Gum Pain||1 (<1%)||6 (3%)|
|Bronchitis||7 (3%)||5 (2%)|
|Muscle Pain||2 (1%)||6 (3%)|
Note: Percentages are based on total number of study participants in each treatment group.
Adverse Reactions for Tetracyclines: The following adverse reactions have been observed in patients receiving tetracyclines:
Gastrointestinal: anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory lesions (with vaginal candidiasis) in the anogenital region. Hepatotoxicity has been reported rarely. Rare instances of esophagitis and esophageal ulcerations have been reported in patients receiving the capsule forms of the drugs in the tetracycline class. Most of these patients took medications immediately before going to bed. (See DOSAGE AND ADMINISTRATION Section).
Renal toxicity: Rise in BUN has been reported and is apparently dose related. (See WARNINGS Section).
Read the Periostat (doxycycline hyclate) Side Effects Center for a complete guide to possible side effects
Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.
Since bacterial antibiotics, such as the tetracycline class of antibiotics, may interfere with the bactericidal action of members of the -lactam (e.g. penicillin) class of antibiotics, it is not advisable to administer these antibiotics concomitantly.
Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and ironcontaining preparations, and by bismuth subsalicylate.
Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.
The concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity.
Concurrent use of tetracyclines may render oral contraceptives less effective.
Drug/Laboratory Test Interactions: False elevations of urinary catecholamine levels may occur due to interference with the fluorescence test.
Read the Periostat Drug Interactions Center for a complete guide to possible interactions
Last reviewed on RxList: 10/29/2008
This monograph has been modified to include the generic and brand name in many instances.
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