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Periostat

Last reviewed on RxList: 1/25/2017
Periostat Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 02/17/2017

Periostat (doxycycline hyclate) is a tetracycline antibiotic indicated for use as an adjunct to dental procedures including scaling and root planning to promote attachment level gain and to reduce pocket depth in patients with adult periodontitis. Side effects of Periostat include:

  • severe headache,
  • dizziness,
  • blurred vision,
  • nausea,
  • diarrhea,
  • upset stomach,
  • skin rash or itching, or
  • vaginal itching or discharge.

Tell your doctor if you have serious side effects of Periostat including:

  • sunburn (sun sensitivity),
  • painful or difficult swallowing, or
  • a change in the amount of urine.

Periostat dosage differs from that of doxycycline used to treat infections. Exceeding the recommended dosage may result in an increased incidence of side effects including the development of resistant microorganisms. Periostat is taken orally in capsule form. Tell your doctor if you become pregnant while taking Periostat. Periostat may interact with cholesterol-lowering medications, isotretinoin, tretinoin, antacids, products containing bismuth subsalicylate (such as Pepto-Bismol), minerals such as iron, zinc, calcium, magnesium, and over-the-counter vitamin and mineral supplements, blood thinners, or penicillin antibiotics. Tell your doctor all medications and supplements you use. Results from animal studies indicate that doxycycline crosses the placenta and is found in fetal tissues. The use of Periostat may cause discoloration of the teeth in the fetus when administered in the last half of pregnancy and may discolor the teeth when taken as an infant or child up to age 8 years. Talk to your doctor about using birth control while taking Periostat. Periostat passes into breast milk and may affect bone and tooth development in a nursing baby. Breastfeeding while taking Periostat is not recommended.

Our Periostat (doxycycline hyclate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Periostat Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • severe headache, dizziness, blurred vision;
  • fever, chills, body aches, flu symptoms, swollen glands, rash or itching, joint pain, or general ill feeling;
  • urinating less than usual or not at all;
  • diarrhea that is watery or bloody
  • pale or yellowed skin, dark colored urine, fever, confusion or weakness;
  • severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
  • loss of appetite, jaundice (yellowing of the skin or eyes); or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • mild nausea, mild diarrhea;
  • upset stomach;
  • mild skin rash or itching; or
  • vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Periostat (Doxycycline Hyclate)

Periostat Professional Information

SIDE EFFECTS

Adverse Reactions in Clinical Trials of a bioequivalent form of doxycycline hyclate capsules: In clinical trials of adult patients with periodontal disease 213 patients received 20 mg BID over a 9 - 12 month period. The most frequent adverse reactions occurring in studies involving treatment with a bioequivalent form of doxycycline hyclate capsules or placebo are listed below:

Incidence (%) of Adverse Reactions in Clinical Trials of Doxycycline Hyclate Capsules, 20mg (Bioequivalent to Doxycycline Hyclate Tablets, 20mg) vs. Placebo

Adverse Reaction Doxycycline Hyclate
Capsules 20 mg BID
(n=213)
Placebo
(n=215)
Headache 55 (26%) 56 (26%)
Common Cold 47 (22%) 46 (21%)
Flu Symptoms 24 (11%) 40 (19%)
Tooth Ache 14 (7%) 28 (13%)
Periodontal Abscess 8 (4%) 21 (10%)
Tooth Disorder 13 (6%) 19 (9%)
Nausea 17 (8%) 12 (6%)
Sinusitis 7 (3%) 18 (8%)
Injury 11 (5%) 18 (8%)
Dyspepsia 13 (6%) 5 (2%)
Sore Throat 11 (5%) 13 (6%)
Joint Pain 12 (6%) 8 (4%)
Diarrhea 12 (6%) 8 (4%)
Sinus Congestion 11 (5%) 11 (5%)
Coughing 9 (4%) 11 (5%)
Sinus Headache 8 (4%) 8 (4%)
Rash 8 (4%) 6 (3%)
Back Pain 7 (3%) 8 (4%)
Back Ache 4 (2%) 9 (4%)
Menstrual Cramp 9 (4%) 5 (2%)
Acid Indigestion 8 (4%) 7 (3%)
Pain 8 (4%) 5 (2%)
Infection 4 (2%) 6 (3%)
Gum Pain 1 (<1%) 6 (3%)
Bronchitis 7 (3%) 5 (2%)
Muscle Pain 2 (1%) 6 (3%)

Note: Percentages are based on total number of study participants in each treatment group.

Adverse Reactions for Tetracyclines: The following adverse reactions have been observed in patients receiving tetracyclines:

Gastrointestinal: anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory lesions (with vaginal candidiasis) in the anogenital region. Hepatotoxicity has been reported rarely. Rare instances of esophagitis and esophageal ulcerations have been reported in patients receiving the capsule forms of the drugs in the tetracycline class. Most of these patients took medications immediately before going to bed. (See DOSAGE AND ADMINISTRATION Section).

Skin: maculopapular and erythematous rashes. Exfoliative dermatitis has been reported but is uncommon. Photosensitivity is discussed above. (See WARNINGS Section).

Renal toxicity: Rise in BUN has been reported and is apparently dose related. (See WARNINGS Section).

Hypersensitivity reactions: urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, and exacerbation of systemic lupus erythematosus.

Blood: Hemolytic anemia, thrombocytopenia, neutropenia, and eosinophilia have been reported.

Read the entire FDA prescribing information for Periostat (Doxycycline Hyclate)

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© Periostat Patient Information is supplied by Cerner Multum, Inc. and Periostat Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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