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(Generic versions may still be available.)
Permax (pergolide mesylate) is indicated as adjunctive treatment to levodopa/carbidopa in the management of the signs and symptoms of Parkinson†s disease.
Evidence to support the efficacy of pergolide mesylate as an antiparkinsonian adjunct was obtained in a multicenter study enrolling 376 patients with mild to moderate Parkinson†s disease who were intolerant to l-dopa/carbidopa as manifested by moderate to severe dyskinesia and/or on-off phenomena. On average, the patients evaluated had been on l-dopa/carbidopa for 3.9 years (range, 2 days to 16.8 years). The administration of pergolide mesylate permitted a 5% to 30% reduction in the daily dose of l/dopa. On average, these patients treated with pergolide mesylate maintained an equivalent or better clinical status than they exhibited at baseline.
DOSAGE AND ADMINISTRATION
Administration of Permax (pergolide mesylate) should be initiated with a daily dosage of 0.05 mg for the first 2 days. The dosage should then be gradually increased by 0.1 or 0.15 mg/day every third day over the next 12 days of therapy. The dosage may then be increased by 0.25 mg/day every third day until an optimal therapeutic dosage is achieved.
Permax (pergolide mesylate) is usually administered in divided doses 3 times per day. During dosage titration, the dosage of concurrent l-dopa/carbidopa may be cautiously decreased.
In clinical-studies, the mean therapeutic daily dosage of Permax (pergolide mesylate) was 3 mg/day. The average concurrent daily dosage of l-dopa/carbidopa (expressed as l-dopa) was approximately 650 mg/day. The efficacy of Permax (pergolide mesylate) at doses above 5 mg/day has not been systematically evaluated.
- 0.05 mg, ivory, debossed with A615, (UC5336)-(RxPak* of 30) NDC 59075-615-30
- 0.25 mg, green, debossed with A625, (UC5337)-(RxPak of 100) NDC 59075-625-10
- 1 mg, pink, debossed with A630, (UC5338)--(RxPak of 100) NDC 59075-630-10
*All RxPaks (prescription packages, Lilly) have safety closures.
Store at controlled room temperature, 59 to 86° F (15 to 30° C ).
CAUTION-Federal (USA) law prohibits dispensing without prescription.
Updated Apr 08, 2003This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 12/8/2004
Additional Permax Information
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