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Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Permax Patient Information Including Side Effects

Brand Names: Permax

Generic Name: pergolide (Pronunciation: PER go lide)

What is pergolide (Permax)?

Pergolide was withdrawn from the U.S. market on March 29, 2007.

Pergolide is used to treat Parkinson's disease. Parkinson's disease is associated with low levels of a chemical called dopamine (DOE pa meen) in the brain. Pergolide has some of the same effects as dopamine in the body.

Pergolide is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. Pergolide is often used in conjunction with other medicines in the treatment of Parkinson's disease.

Pergolide may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of pergolide (Permax)?

Stop taking pergolide and seek emergency medical attention or contact your doctor immediately if you experience any of the following serious side effects:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
  • irregular heartbeats;
  • hallucinations (seeing or hearing things that are not real), confusion, or altered consciousness; or
  • dizziness (especially when rising from a sitting or lying position).

Other, less serious side effects may be more likely to occur. Continue to take pergolide and talk to your doctor if you experience

  • mild nausea, vomiting, upset stomach, or decreased appetite;
  • diarrhea or constipation;
  • dry mouth;
  • drowsiness;
  • insomnia; or
  • agitation or anxiety.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Read the Permax (pergolide mesylate) Side Effects Center for a complete guide to possible side effects

What is the most important information I should know about pergolide (Permax)?

Pergolide was withdrawn from the U.S. market on March 29, 2007.

Use caution when driving, operating machinery, or performing other hazardous activities. Pergolide may cause drowsiness or low blood pressure (leading to dizziness and other symptoms), especially when rising from a sitting or lying position. Rise slowly and use caution when performing hazardous activities until you know how this medication affects you.

Do not stop taking pergolide without first talking to your doctor. Stopping pergolide suddenly may cause potentially dangerous side effects such as elevated body temperature, muscle rigidity, confusion or altered consciousness, and other problems.

Side Effects Centers

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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