Permax (Pergolide Mesylate) Patient Information: Side Effects and Drug Images at RxList

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May 27, 2012

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Parkinson's Disease »

What is Parkinson's disease?

Parkinson's disease is the second most common neurodegenerative disorder and the most common movement disorder. It is characterized by progressive loss of muscle control, which leads to trembling of the limbs and head while at rest, stiffness, slowness, and impaired balance. As symptoms worsen, it may become difficult to walk, talk, and complete simple tasks.

The progression of Parkinson's disease and the degree of impairment vary from individual to individual. Many people with Parkinson's disease live long productive lives, whereas others become disabled much more quickly. Premature death is usually due to complications such as falling-related injuries or pneumonia.

In the United States, about 1 million people are affected by Parkinson's disease and worldwide about 5 million. Most individuals who develop Parkinson's disease are 60 years of age or older. Parkinson's disease occurs in approximately 1% of i...

Read the Parkinson's Disease article »

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Permax Patient Information Including Side Effects

Brand Names: Permax

Generic Name: pergolide (Pronunciation: PER go lide)

What is pergolide (Permax)?

Pergolide was withdrawn from the U.S. market on March 29, 2007.

Pergolide is used to treat Parkinson's disease. Parkinson's disease is associated with low levels of a chemical called dopamine (DOE pa meen) in the brain. Pergolide has some of the same effects as dopamine in the body.

Pergolide is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. Pergolide is often used in conjunction with other medicines in the treatment of Parkinson's disease.

Pergolide may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of pergolide (Permax)?

Stop taking pergolide and seek emergency medical attention or contact your doctor immediately if you experience any of the following serious side effects:

an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
irregular heartbeats;
hallucinations (seeing or hearing things that are not real), confusion, or altered consciousness; or
dizziness (especially when rising from a sitting or lying position).

Other, less serious side effects may be more likely to occur. Continue to take pergolide and talk to your doctor if you experience

mild nausea, vomiting, upset stomach, or decreased appetite;
diarrhea or constipation;
dry mouth;
drowsiness;
insomnia; or
agitation or anxiety.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What is the most important information I should know about pergolide (Permax)?

Pergolide was withdrawn from the U.S. market on March 29, 2007.

Use caution when driving, operating machinery, or performing other hazardous activities. Pergolide may cause drowsiness or low blood pressure (leading to dizziness and other symptoms), especially when rising from a sitting or lying position. Rise slowly and use caution when performing hazardous activities until you know how this medication affects you.

Do not stop taking pergolide without first talking to your doctor. Stopping pergolide suddenly may cause potentially dangerous side effects such as elevated body temperature, muscle rigidity, confusion or altered consciousness, and other problems.

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