Perphenazine Tablets (Perphenazine) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Perphenazine

Nausea and Vomiting »

Introduction to nausea and vomiting

Nausea and vomiting are symptoms of an underlying disease and not a specific illness. Nausea is the sensation that the stomach wants to empty itself, while vomiting (emesis) or throwing up, is the act of forcible emptying of the stomach.

Vomiting is a violent act in which the stomach has to overcome the pressures that are normally in place to keep food and secretions within the stomach. The stomach almost turns itself inside out - forcing itself into the lower portion of the esophagus (the tube that connects the mouth to the stomach) during a vomiting episode.

What causes nausea or vomiting?

There are numerous causes of nausea and vomiting. These symptoms may be due to the following:

acute gastritis
central causes (signals from the brain)
association with other illnesses remote from the stomach
medications and medical treatments

Read the Nausea and Vomiting article »

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Perphenazine (perphenazine)
Tablets, USP

DRUG DESCRIPTION

Perphenazine (perphenazine) (4-[3-(2-chlorophenothiazin-10-yl)propyl]-1-piperazineethanol), a piperazinyl phenothiazine, having the chemical formula, C₂₁H₂₆CIN₃OS. It is available as oral tablets containing 2 mg, 4 mg, 8 mg, and 16 mg of perphenazine (perphenazine) .

Inactive ingredients: lactose (monohydrate), hydroxypropyl cellulose, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, starch (corn), titanium dioxide, and polysorbate 80. Its structural formula is:

Perphenazine Structural Formula Illustration

Actions

Perphenazine (perphenazine) has actions at all levels of the central nervous system, particularly the hypothalamus. However, the site and mechanism of action of therapeutic effect are not known.

What are the possible side effects of perphenazine (Trilafon)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using perphenazine and call your doctor at once if you have a serious side effect such as:

twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
feeling restless, jittery, or agitated;
confusion,...

Read All Potential Side Effects and See Pictures of Perphenazine Tablets »

What are the precautions when taking perphenazine (Perphenazine Tablets)?

Before taking perphenazine, tell your doctor or pharmacist if you are allergic to it, or to other phenothiazines (e.g., chlorpromazine, fluphenazine), or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: decreased bone marrow function, serious head injury, severe liver problems, severe nervous system problem (e.g., coma, drug/alcohol overdose, shock), Parkinson's disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of alcohol/substance...

Read All Potential Precautions of Perphenazine Tablets »

Last reviewed on RxList: 10/21/2008
This monograph has been modified to include the generic and brand name in many instances.