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Persantine Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Persantine (dipyridamole) is a platelet inhibitor used to prevent blood clots after heart valve replacement surgery. Persantine is available in generic form. Common side effects of Persantine include dizziness, stomach upset, diarrhea, vomiting, headache, and flushing (warmth, redness, or tingly feeling under your skin), particularly at first as your body adjusts to the medication. Other side effects of Persantine include muscle or joint pain, headache, or skin rash or itching.
The recommended dose of Persantine is 75-100 mg four times daily as an adjunct to the usual warfarin therapy. Persantine may interact with non-steroidal anti-inflammatory drugs (NSAIDs) or other blood thinners such as warfarin (Coumadin). Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. During pregnancy, Persantine should be used only when prescribed. This medication passes into breast milk. Consult your doctor before breast-feeding.
Our Persantine (dipyridamole USP) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Persantine in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- nosebleed or other bleeding that will not stop;
- black, bloody, or tarry stools; or
- coughing up blood or vomit that looks like coffee grounds.
Less serious side effects may include:
- upset stomach, diarrhea, vomiting;
- warmth, redness, or tingly feeling under your skin;
- muscle or joint pain;
- headache; or
- mild skin rash or itching.
Read the entire detailed patient monograph for Persantine (Dipyridamole)
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Persantine Overview - Patient Information: Side Effects
To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: fainting, stomach pain, yellowing eyes/skin, dark urine, unusual bleeding/bruising.
Get medical help right away if you have any very serious side effects, including: chest pain, severe headache, weakness on one side of the body, vision changes, slurred speech, confusion.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Persantine (Dipyridamole)
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Persantine FDA Prescribing Information: Side Effects
Adverse reactions at therapeutic doses are usually minimal and transient. On long-term use of Persantine (dipyridamole USP) tablets initial side effects usually disappear. The following reactions in Table 1 were reported in two heart valve replacement trials comparing Persantine (dipyridamole) E tablets and warfarin therapy to either warfarin alone or warfarin and placebo:
Table 1: Adverse Reactions Reported in 2 Heart Valve Replacement
|Tablets / Warfarin||Placebo/ Warfarin|
|Number of patients||147||170|
Other reactions from uncontrolled studies include diarrhea, vomiting, flushing and pruritus. In addition, angina pectoris has been reported rarely and there have been rare reports of liver dysfunction. On those uncommon occasions when adverse reactions have been persistent or intolerable, they have ceased on withdrawal of the medication.
When Persantine (dipyridamole) tablets were administered concomitantly with warfarin, bleeding was no greater in frequency or severity than that observed when warfarin was administered alone. In rare cases, increased bleeding during or after surgery has been observed.
In post-marketing reporting experience, there have been rare reports of hypersensitivity reactions (such as rash, urticaria, severe bronchospasm, and angioedema), larynx edema, fatigue, malaise, myalgia, arthritis, nausea, dyspepsia, paresthesia, hepatitis, thrombocytopenia, alopecia, cholelithiasis, hypotension, palpitation, and tachycardia.
Read the entire FDA prescribing information for Persantine (Dipyridamole)
Additional Persantine Information
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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