Peyronie's Disease (Curvature of the Penis) (cont.)
Charles Patrick Davis, MD, PhD
Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.
Jerry R. Balentine, DO, FACEP
Dr. Balentine received his undergraduate degree from McDaniel College in Westminster, Maryland. He attended medical school at the Philadelphia College of Osteopathic Medicine graduating in1983. He completed his internship at St. Joseph's Hospital in Philadelphia and his Emergency Medicine residency at Lincoln Medical and Mental Health Center in the Bronx, where he served as chief resident.
In this Article
- Peyronie's disease facts
- What is Peyronie's disease?
- What causes Peyronie's disease?
- What are the symptoms of Peyronie's disease?
- What are the phases of Peyronie's disease?
- How is Peyronie's disease diagnosed?
- What is the treatment for Peyronie's disease ?
- Medications, Vitamins, and Supplements
- Shockwave therapy
- Other therapies
- What are the complications of Peyronie's disease?
- What is the prognosis for Peyronie's disease?
- Find a local Doctor in your town
What is the treatment for Peyronie's disease ?
There is no treatment that will cure Peyronie's disease. However, there are several types of treatments that are designed to reduce the symptoms of the disease.
Medications, Vitamins, and Supplements
In December, 2013, the FDA approved collagenase clostridium histolyticum (Xiaflex) to treat individuals with Peyronie's disease. Each treatment cycle consists of two see if Lex injections into the collagen - containing structure the penis to break up the collagen that causes the curvature deformity. Treatments consist of a maximum four injections. Betamethasone has also been tried experimentally to diminish penile curvature with some success.
Oral therapy with vitamin E, colchicine, PABA, tamoxifen, and other medications have been tried with limited success in some patients. Usually those in the acute phase of the disease responded best.
In the early stages of the disease, erectile dysfunction (ED) may be treated with such drugs as sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis, Adcirca).
Injection therapy using combinations of drugs mentioned above and adding prostaglandin E1 or other drugs such as betamethasone alone or with hyaluronidase; PABA has been reported to reduce the penile plaque size.
Other drugs have also been used with varying degree of success. Verapamil (Calan, Verelan, Verelan PM, Isoptin, Isoptin SR, Covera-HS [a medication usually used for high blood pressure treatment]) appears to disrupt the production of a protein involved in the formation of Peyronie's disease leisons.
Another method is iontophoresis (also termed electromotive administration or EMDA) where verapamil and other drugs are applied to the penile skin and pushed through the skin with a low electrical current.
Shockwave therapy (done with a lithotripter device like those used to break up kidney stones) has been used on plaque or scaring that is calcified. Other mechanical devices, including vacuum-based machines and low-dose radiotherapy have been tried. Although some successes are seen with these methods, best results are in acute phase patients. There are ongoing studies with different drugs (for example, interferons, and collagenase) and surgical techniques.
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