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Phenergan-Codeine

Last reviewed on RxList: 2/26/2015
Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Phenergan-Codeine Side Effects Center

Last reviewed on RxList 11/07/2016

Phenergan-Codeine (codeine and promethazine) is a combination of a narcotic that acts a pain reliever and a cough suppressant, and an antihistamine, used to treat cold or allergy symptoms such as runny nose, sneezing, and cough. The brand name Phenergan-Codeine is no longer available in the U.S. Generic versions may be available. Common side effects of Phenergan-Codeine (codeine and promethazine) include:

  • drowsiness,
  • dizziness,
  • sleepiness,
  • headache,
  • lightheadedness,
  • restlessness,
  • nervousness,
  • anxiety,
  • blurred vision,
  • ringing in your ears,
  • upset stomach,
  • nausea,
  • vomiting,
  • constipation,
  • sleep problems (insomnia),
  • increased sweating,
  • dry mouth,
  • skin rash, or
  • flushing (warmth, redness, or tingly feeling under your skin).

Tell your doctor if you have unlikely but serious side effects of Phenergan-Codeine including:

  • involuntary behaviors or movements (e.g., fixed upward stare, neck twisting, tongue movements),
  • mental/mood changes (e.g., hallucinations, confusion),
  • shaking (tremors),
  • trouble urinating, or
  • weakness.

The adult dose of codeine and promethazine is 1 tsp (5 ml) every 4 to 6 hours, not to exceed 30 ml in 24 hours. Pediatric dose is based on the child's weight. Codeine and promethazine may interact with sedatives or anxiety medicines, antidepressants, narcotics, phenobarbital, amobarbital, secobarbital, MAO inhibitors, atropine, belladonna, clidinium, dicyclomine, glycopyrrolate, hyoscyamine, methscopolamine, and scopolamine. Tell your doctor all medications you use. During pregnancy, this drug should be used only if prescribed. It is not recommended for use during the last 3 months of pregnancy due to increased risk for withdrawal symptoms such as irritability, abnormal/persistent crying, diarrhea, or seizures. Tell your doctor if you notice symptoms in your newborn. This product passes into breast milk and may rarely have undesirable effects on a nursing infant. Tell your doctor if your infant develops increased sleepiness, difficulty feeding, or trouble breathing. Consult your doctor before breastfeeding. The codeine in this medication may be habit-forming. Withdrawal symptoms may occur if you suddenly stop taking this drug.

Our Phenergan-Codeine (codeine and promethazine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Phenergan-Codeine Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • restless muscle movements in your eyes, tongue, jaw, or neck, tremor (uncontrolled shaking);
  • shallow breathing, slow heartbeat;
  • feeling like you might pass out;
  • jaundice (yellowing of the skin or eyes);
  • confusion, agitation, hallucinations, unusual thoughts or behavior;
  • seizure (convulsions);
  • urinating less than usual or not at all; or
  • very stiff (rigid) muscles, high fever, sweating, fast or uneven heartbeats, fainting.

Less serious side effects may include:

  • dizziness, drowsiness, sleepiness;
  • feeling restless, nervous, or anxious;
  • blurred vision, ringing in your ears;
  • constipation, mild nausea or vomiting;
  • warmth, redness, or tingly feeling under your skin;
  • sleep problems (insomnia);
  • increased sweating;
  • dry mouth; or
  • mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Phenergan-Codeine (Codeine Phosphate and Promethazine HCl)

Phenergan-Codeine Professional Information

SIDE EFFECTS

Codeine

Central Nervous System

CNS depression, particularly respiratory depression, and to a lesser extent circulatory depression; light-headedness, dizziness, sedation, euphoria, dysphoria, headache, transient hallucination, disorientation, visual disturbances, and convulsions.

Cardiovascular

Tachycardia, bradycardia, palpitation, faintness, syncope, orthostatic hypotension (common to narcotic analgesics).

Gastrointestinal

Nausea, vomiting, constipation, and biliary tract spasm. Patients with chronic ulcerative colitis may experience increased colonic motility; in patients with acute ulcerative colitis, toxic dilation has been reported.

Genitourinary

Oliguria, urinary retention, antidiuretic effect has been reported (common to narcotic analgesics).

Allergic

Infrequent pruritus, giant urticaria, angioneurotic edema, and laryngeal edema.

Other

Flushing of the face, sweating and pruritus (due to opiate-induced histamine release); weakness.

Promethazine

Central Nervous System

Drowsiness is the most prominent CNS effect of this drug. Sedation, somnolence, blurred vision, dizziness, confusion, disorientation and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Hallucinations have also been reported.

Cardiovascular

Increased or decreased blood pressure, tachycardia, bradycardia, faintness.

Dermatologic

Dermatitis, photosensitivity, urticaria.

Hematologic

Leukopenia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis.

Gastrointestinal

Dry mouth, nausea, vomiting, jaundice.

Respiratory

Asthma, nasal stuffiness, respiratory depression (potentially fatal) and apnea (potentially fatal) (see WARNINGS - Promethazine; Respiratory Depression).

Other

Angioneurotic edema. Neuroleptic malignant syndrome (potentially fatal) has also been reported (see WARNINGS - Promethazine; Neuroleptic Malignant Syndrome).

Paradoxical Reactions

Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine HCl. Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur. Respiratory depression, nightmares, delirium and agitated behavior have also been reported in some of these patients.

Drug Abuse And Dependence

Controlled Substance

Promethazine HCl and Codeine Phosphate Oral Solution is a Schedule V Controlled Substance.

Abuse

Codeine is known to be subject to abuse; however, the abuse potential of oral codeine appears to be quite low. Even parenteral codeine does not appear to offer the psychic effects sought by addicts to the same degree as heroin or morphine. However, codeine must be administered only under close supervision to patients with a history of drug abuse or dependence.

Dependence

Psychological dependence, physical dependence, and tolerance are known to occur with codeine.

Read the entire FDA prescribing information for Phenergan-Codeine (Codeine Phosphate and Promethazine HCl)

Related Resources for Phenergan-Codeine

Related Health

Read the Phenergan-Codeine User Reviews »

© Phenergan-Codeine Patient Information is supplied by Cerner Multum, Inc. and Phenergan-Codeine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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