Phenergan (Promethazine) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 3, 2012

Phenergan

Vertigo »

Vertigo introduction

Balance is defined as a state of equilibrium. It takes significant amount of work for this to occur in the body. The brain uses inputs from many sources to understand where the body is located in relationship to the world and to allow it to function. Sensory information from the eyes, ears, and position receptors in the rest of the body help keep the body upright and allow it to move in a coordinated fashion.

Information comes to cerebellar lobes located in the base of the brain from the vestibular system in the inner ear, vision from the eyes, and proprioception (position) receptors located throughout the body that send signals through the spinal cord. The cerebellum uses that information to maintain posture, coordinate body motions like walking and also coordinate fine motor skills like using a pen to write.

Vertigo, a feeling of spinning movement and sometimes accompanied by nausea and vomiting, occurs when an...

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Phenergan

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Please Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Phenergan®
(promethazine HCI)
Tablets and Suppositories

DRUG DESCRIPTION

Each tablet of Phenergan contains 12.5 mg, 25 mg, or 50 mg promethazine HCl. The inactive ingredients present are lactose, magnesium stearate, and methylcellulose. Each dosage strength also contains the following:

12.5 mg-FD&C Yellow 6 and saccharin sodium;
25 mg-saccharin sodium;
50 mg-FD&C Red 40.

Each rectal suppository of Phenergan contains 12.5 mg, 25 mg, or 50 mg promethazine HCl with ascorbyl palmitate, silicon dioxide, white wax, and cocoa butter. Phenergan (promethazine) Suppositories are for rectal administration only.

Promethazine HCl is a racemic compound; the empirical formula is C₁₇H₂₀N₂S•HCl and its molecular weight is 320.88.

Promethazine HCl, a phenothiazine derivative, is designated chemically as 10H-Phenothiazine-10-ethanamine, N,N,alpha;-trimethyl-, monohydrochloride, (±)- with the following structural formula:

Phenergan (promethazine HCI) structural formula illustration

Promethazine HCl occurs as a white to faint yellow, practically odorless, crystalline powder which slowly oxidizes and turns blue on prolonged exposure to air. It is freely soluble in water and soluble in alcohol.

What are the possible side effects of oral promethazine (Pentazine, Phenergan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using promethazine and call your doctor at once if you have any of these serious side effects:

twitching, or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
feeling restless, jittery, or agitated;

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