"The U.S. Food and Drug Administration recently approved Oralair to treat allergic rhinitis (hay fever) with or without conjunctivitis (eye inflammation) that is induced by certain grass pollens in people ages 10 through 65 years. Oralair is the f"...
(Generic versions may still be available.)
Phenergan (Promethazine HCl) Suppositories, USP are useful for:
Perennial and seasonal allergic rhinitis.
Amelioration of allergic reactions to blood or plasma.
Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled.
Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery.
Therapy adjunctive to meperidine or other analgesics for control of postoperative pain.
Sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient can be easily aroused.
Antiemetic therapy in postoperative patients.
DOSAGE AND ADMINISTRATION
Phenergan (Promethazine HCl) Suppositories are contraindicated for children under 2 years of age (see WARNINGS – Black Box Warning and Use in Pediatric Patients).
Phenergan (Promethazine HCl) Suppositories are for rectal administration only.
The average dose is 25 mg taken before retiring; however, 12.5 mg may be taken before meals and on retiring, if necessary. Single 25-mg doses at bedtime or 6.25 to 12.5 mg taken three times daily will usually suffice. After initiation of treatment in children or adults, dosage should be adjusted to the smallest amount adequate to relieve symptoms. The administration of promethazine hydrochloride in 25- mg doses will control minor transfusion reactions of an allergic nature.
The average adult dose is 25 mg taken twice daily. The initial dose should be taken one-half to one hour before anticipated travel and be repeated 8 to 12 hours later, if necessary. On succeeding days of travel, it is recommended that 25 mg be given on arising and again before the evening meal. For children, Phenergan (Promethazine HCl) Rectal Suppositories, 12.5 to 25 mg, twice daily, may be administered.
Nausea And Vomiting
The average effective dose of promethazine HCl for the active therapy of nausea and vomiting in children or adults is 25 mg. 12.5- to 25-mg doses may be repeated, as necessary, at 4- to 6-hour intervals.
For nausea and vomiting in children, the usual dose is 0.5 mg per pound of body weight, and the dose should be adjusted to the age and weight of the patient and the severity of the condition being treated.
For prophylaxis of nausea and vomiting, as during surgery and the postoperative period, the average dose is 25 mg repeated at 4- to 6-hour intervals, as necessary.
This product relieves apprehension and induces a quiet sleep from which the patient can be easily aroused. Administration of 12.5 to 25 mg promethazine HCl by rectal suppository at bedtime will provide sedation in children. Adults usually require 25 to 50 mg for nighttime, presurgical, or obstetrical sedation.
Pre- And Postoperative Use
Promethazine HCl in 12.5- to 25-mg doses for children and 50-mg doses for adults the night before surgery relieves apprehension and produces a quiet sleep.
For preoperative medication children require doses of 0.5 mg per pound of body weight in combination with an appropriately reduced dose of narcotic or barbiturate and the appropriate dose of an atropinelike drug. Usual adult dosage is 50 mg promethazine HCl with an appropriately reduced dose of narcotic or barbiturate and the required amount of a belladonna alkaloid.
Postoperative sedation and adjunctive use with analgesics may be obtained by the administration of 12.5 to 25 mg in children and 25- to 50-mg doses in adults.
Phenergan (Promethazine HCl) Rectal Suppositories are not recommended for children under 2 years of age.
Phenergan (Promethazine HCl) Rectal Suppositories, USP are available in boxes of 12 as follows:
12.5 mg, white, bullet-shaped suppository wrapped in silver foil. Box of 12 NDC 40076-318-12
25 mg, white, bullet-shaped suppository wrapped in silver foil. Box of 12 NDC 40076-319-12
Store refrigerated between 2°-8°C (36°-46°F).
Dispense in well-closed container.
Manufactured for: Prestium Pharma, Inc., Newtown, PA 18940. By: G&W Laboratories, Inc., South Plainfield, NJ 07080. Revised: Jun 2014This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 9/6/2016
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