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Phenergan Side Effects Center
Medical Editor: Melissa Conrad Stöppler, MD
Phenergan (promethazine HCI) is an antihistamine used to treat nausea and vomiting related to certain conditions (e.g., motion sickness, before/after surgery). It is also used to treat allergic symptoms such as rash, itching, and runny nose. Phenergan is available as a generic drug, and is usually taken four times daily as needed or as directed by your doctor. The most common side effects of Phenergan are drowsiness, dizziness, or anxiety.
Drug interactions and warnings include: Concomitant use of other agents with anticholinergic properties should be undertaken with caution. Phenergan Tablets and Suppositories should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Phenergan is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants from Phenergan Tablets and Suppositories, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Our Phenergan Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information in Detail?
Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.
Phenergan in Detail - Patient Information: Side Effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using promethazine and call your doctor at once if you have any of these serious side effects:
- twitching, or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
- tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;
- feeling restless, jittery, or agitated;
- high fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing;
- feeling like you might pass out;
- seizure (convulsions);
- pale skin, easy bruising or bleeding, fever, sore throat, flu symptoms;
- decreased night vision, tunnel vision, watery eyes, increased sensitivity to light;
- hallucinations, agitation;
- nausea and stomach pain, skin rash, and jaundice (yellowing of the skin or eyes);
- urinating less than usual or not at all;
- joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color; or
- slow heart rate, weak pulse, fainting, slow breathing (breathing may stop).
Less serious side effects may include:
- dizziness, drowsiness, anxiety;
- blurred vision, dry mouth, stuffy nose;
- ringing in your ears;
- weight gain, swelling in your hands or feet;
- impotence, trouble having an orgasm; or
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Phenergan (Promethazine) »
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Phenergan Overview - Patient Information: Side Effects
To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: fainting, slow heartbeat, mental/mood changes (such as hallucinations, nervousness, irritability, restlessness, confusion), unusual/uncontrolled movements (such as fixed upward stare, neck twisting, tongue movements), shaking (tremor), difficulty urinating, easy bleeding/bruising, signs of infection (such as fever, persistent sore throat), severe stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin.
Get medical help right away if you have any very serious side effects, including: slow/shallow breathing, seizures.
This medication may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Get medical help right away if you have any of the following symptoms: fever, muscle stiffness/pain/tenderness/weakness, severe tiredness, severe confusion, sweating, fast/irregular heartbeat, dark urine, change in the amount of urine.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Phenergan (Promethazine)»
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Phenergan FDA Prescribing Information: Side Effects
Central Nervous System
Drowsiness is the most prominent CNS effect of this drug. Sedation, somnolence, blurred vision, dizziness; confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Hallucinations have also been reported.
Dry mouth, nausea, vomiting, jaundice.
Angioneurotic edema. Neuroleptic malignant syndrome (potentially fatal) has also been reported. (See WARNINGS-Neuroleptic Malignant Syndrome.)
Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine HCl. Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur. Respiratory depression, nightmares, delirium, and agitated behavior have also been reported in some of these patients.
Read the entire FDA prescribing information for Phenergan (Promethazine) »
Additional Phenergan Information
Phenergan - User Reviews
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