July 25, 2016
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Phenergan Vc

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Phenergan Vc

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Side Effects



Nervous System: Sedation, sleepiness, occasional blurred vision, dryness of mouth, dizziness; rarely: confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion (usually in association with parenteral injection or excessive dosage).

Cardiovascular: Increased or decreased blood pressure.

Dermatologic: Rash; rarely: photosensitivity.

Hematologic: Rarely: leukopenia, thrombocytopenia; agranulocytosis (1 case).

Gastrointestinal: Nausea and vomiting.


Nervous System: Restlessness, anxiety, nervousness, and dizziness.

Cardiovascular: Hypertension (see WARNINGS).

Other: Precordial pain, respiratory distress, tremor, and weakness.

Read the Phenergan Vc (promethazine hcl and phenylephrine hcl syrup) Side Effects Center for a complete guide to possible side effects



The sedative action of promethazine is additive to the sedative effects of other central nervous system depressants, including alcohol, narcotic analgesics, sedatives, hypnotics, tricyclic antidepressants, and tranquilizers; therefore, these agents should be avoided or administered in reduced dosage to patients receiving promethazine.


Drug: Phenylephrine with prior administration of monoamine oxidase inhibitors (MAOI).

Drug: Phenylephrine with tricyclic antidepressants.

    Effect: Pressor response increased.

Drug: Phenylephrine with ergot alkaloids.

    Effect: Excessive rise in blood pressure.

Drug: Phenylephrine with bronchodilator sympathomimetic agents and with epinephrine or other sympathomimetics.

Drug: Phenylephrine with atropine sulfate.

Drug: Phenylephrine with prior administration of propranolol or other b- adrenergic blockers.

    Effect: Cardiostimulating effects blocked.

Drug: Phenylephrine with prior administration of phentolamine or other a- adrenergic blockers.

    Effect: Pressor response decreased.

Drug: Phenylephrine with diet preparations, such as amphetamines or phenylpropanolamine.

    Effect: Synergistic adrenergic response.

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 12/8/2004

Side Effects

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