July 30, 2016
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Phenergan Vc

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Phenergan Vc

Discontinued Warning IconPlease Note: This Brand Name drug is no longer available in the US.
(Generic versions may still be available.)

Phenergan Vc Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 1/3/2016

Phenergan VC (promethazine HCl and phenylephrine HCl) Syrup is a combination of an antihistamine and a decongestant used to treat symptoms such as itching, runny nose, sneezing, and congestion due to allergies or the common cold. The brand name Phenergan VC is discontinued in the U.S. Generic versions may be available. Common side effects of Phenergan VC (promethazine HCl and phenylephrine HCl) include drowsiness, dizziness, headache, upset stomach, nausea, vomiting, dry mouth, sleepiness, confusion, restlessness, irritability, blurred vision, or increased skin sensitivity to sunlight.

The dose of promethazine and phenylephrine for adults and children 12 years and over: 1 tsp (5 mL) every 4 to 6 hours, not to exceed 6 tsp (30 mL) in 24 hours. Children 6 to under 12 years of age: ½ to 1 tsp (2.5 to 5 mL) every 4 to 6 hours, not to exceed 6 tsp (30 mL) in 24 hours. Children 2 to under 6 years of age: ¼ to ½ tsp (1.25 to 2.5 mL) every 4 to 6 hours. Promethazine and phenylephrine may interact with monoamine oxidase inhibitors (MAOIs), other drugs that cause drowsiness (i.e., antidepressants, alcohol, sedatives, pain relievers, anxiety medicines, and muscle relaxants), other over-the-counter cough, cold, allergy, diet, pain, fever, or sleep medicines. Tell your doctor all prescriptions and over-the-counter medications you use. During pregnancy, promethazine and phenylephrine should be used only if prescribed. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

Our Phenergan VC (promethazine HCl and phenylephrine HCl) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Phenergan Vc in Detail - Patient Information: Side Effects

If you experience any of the following serious side effects, stop taking phenylephrine and promethazine and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or
  • uncontrollable movements of the eyes, lips, tongue, face, arms, or legs.

Other, less serious side effects may be more likely to occur. Continue to take phenylephrine and promethazine and talk to your doctor if you experience

  • dizziness, drowsiness, sleepiness, or confusion;
  • restlessness or irritability;
  • blurred vision or a dry mouth;
  • nausea or vomiting; or
  • increased skin sensitivity to sunlight.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Phenergan Vc (Promethazine HCl and Phenylephrine HCl Syrup)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Phenergan Vc FDA Prescribing Information: Side Effects
(Adverse Reactions)



Nervous System: Sedation, sleepiness, occasional blurred vision, dryness of mouth, dizziness; rarely: confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion (usually in association with parenteral injection or excessive dosage).

Cardiovascular: Increased or decreased blood pressure.

Dermatologic: Rash; rarely: photosensitivity.

Hematologic: Rarely: leukopenia, thrombocytopenia; agranulocytosis (1 case).

Gastrointestinal: Nausea and vomiting.


Nervous System: Restlessness, anxiety, nervousness, and dizziness.

Cardiovascular: Hypertension (see WARNINGS).

Other: Precordial pain, respiratory distress, tremor, and weakness.

Read the entire FDA prescribing information for Phenergan Vc (Promethazine HCl and Phenylephrine HCl Syrup)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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