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Phentolamine Mesylate for Injection

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Phentolamine Mesylate for Injection

CLINICAL PHARMACOLOGY

Phentolamine mesylate (phentolamine mesylate) produces an alpha-adrenergic block of relatively short duration. It also has direct, but less marked, positive inotropic and chronotropic effects on cardiac muscle and vasodilator effects on vascular smooth muscle.

Phentolamine has a half-life in the blood of 19 minutes following intravenous administration. Approximately 13% of a single intravenous dose appears in the urine as unchanged drug.

Last reviewed on RxList: 10/21/2008
This monograph has been modified to include the generic and brand name in many instances.

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