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home > drugs a-z list > phoslo (calcium acetate tablet) drug center > phoslo (calcium acetate tablet) drug - side effects and drug interactions
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Phoslo
What are antacids, and how do they work?
Antacids are a class of drugs used to treat conditions caused by the acid that is produced by the stomach. The stomach naturally secretes an acid called hydrochloric acid that helps to break down proteins. This acid causes the contents of the stomach to be acidic in nature, with a pH level of 2 or 3. (pH levels are a measure of acidity in the stomach: the lower the number, the greater the acidity.) The stomach, duodenum, and esophagus are protected from acid by several protective mechanisms. When there is too much acid or protective mechanisms are inadequate, the lining of the stomach, duodenum or esophagus may become damaged by the acid, giving rise to various gastrointestinal symptoms such as abdominal pain, heartburn (due to gastroesophageal reflux disease or GERD), and other gastro-esophageal symptoms.
Antacids reduce acidity by neutralizing (counteracting) acid, reducing the acidity in the stomac...
Phoslo
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SIDE EFFECTS
In clinical studies, patients have occasionally experienced nausea during PhosLo (calcium acetate tablet) therapy. Hypercalcemia may occur during treatment with PhosLo (calcium acetate tablet) . Mild hypercalcemia (Ca>10.5mg/dL) may be asymptomatic or manifest itself as constipation, anorexia, nausea and vomiting. More severe hypercalcemia (Ca>12mg/dl) is associated with confusion, delirium, stupor and coma. Mild hypercalcemia is easily controlled by reducing the PhosLo (calcium acetate tablet) dose or temporarily discontinuing therapy. Severe hypercalcemia can be treated by acute hemodialysis and discontinuing PhosLo (calcium acetate tablet) therapy. Decreasing dialysate calcium concentration could reduce the incidence and severity of PhosLo (calcium acetate tablet) induced hypercalcemia. The long-term effect of PhosLo (calcium acetate tablet) on the progression of vascular or soft-tissue calcification has not been determined.
Isolated cases of pruritus have been reported which may represent allergic reactions.
DRUG INTERACTIONS
PhosLo (calcium acetate tablet) may decrease the bioavailability of tetracyclines.
Last reviewed on RxList: 5/27/2009
This monograph has been modified to include the generic and brand name in many instances.
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