June 30, 2016

Phosphatidylserine

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What other names is Phosphatidylserine known by?

BC-PS, Bovine Cortex Phosphatidylserine, Bovine Phosphatidylserine, Fosfatidilserina, LECI-PS, Lecithin Phosphatidylserine, Phosphatidylsérine, Phosphatidylsérine Bovine, Phosphatidylsérine de Soya, Phosphatidyl Serine, PS, PtdSer, Soy-PS, Soy Phosphatidylserine.

What is Phosphatidylserine?

Phosphatidylserine is a chemical. The body can make phosphatidylserine, but gets most of what it needs from foods. Phosphatidylserine supplements were once made from cow brains, but now are commonly manufactured from cabbage or soy. The switch was triggered by a concern that products made from animal sources might cause infections such as mad cow disease.

Phosphatidylserine is used for Alzheimer's disease, age-related decline in mental function, improving thinking skills in young people, attention deficit-hyperactivity disorder (ADHD), depression, preventing exercise-induced stress, and improving athletic performance.

Possibly Effective for...

  • Age-related mental decline. Phosphatidylserine made from cow brains seems to improve attention, language skills, and memory in aging people with declining thinking skills. It is not known whether the newer products, which are made from soy and cabbage, will have the same benefit. However, there is developing evidence that plant-derived phosphatidylserine improves memory in people with age-associated memory loss.
  • Alzheimer's disease. Taking phosphatidylserine can improve some of the symptoms of Alzheimer's disease after 6-12 weeks of treatment. It seems to be most effective in people with less severe symptoms. However, phosphatidylserine might lose its effectiveness with extended use. After 16 weeks of treatment, progression of Alzheimer's disease seems to overcome any benefit provided by phosphatidylserine.
    Most clinical studies have used phosphatidylserine from cow brains. However, most supplements now use phosphatidylserine from soy or cabbage. Researchers do not yet know how phosphatidylserine made from these plant sources compares with phosphatidylserine made from cow brains in terms of effectiveness for Alzheimer's disease.

Insufficient Evidence to Rate Effectiveness for...

  • Depression. There is some early evidence that phosphatidylserine might improve depression in older people.
  • Stress brought on by exercise. Some research suggests that athletes taking phosphatidylserine during strenuous training might feel better overall and have less muscle soreness. However, other research shows conflicting results.
  • Improving athletic performance.
  • Improving thinking ability.
  • Attention deficit-hyperactivity disorder (ADHD).
  • Other conditions.
More evidence is needed to rate phosphatidylserine for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).


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