Phospholine Iodide (Echothiophate Iodide for Ophthalmic Solution) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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February 9, 2012

Phospholine

Glaucoma »

What is glaucoma?

Glaucoma is a disease of the major nerve of vision, called the optic nerve. The optic nerve receives light-generated nerve impulses from the retina and transmits these to the brain, where we recognize those electrical signals as vision. Glaucoma is characterized by a particular pattern of progressive damage to the optic nerve that generally begins with a subtle loss of side vision (peripheral vision). If glaucoma is not diagnosed and treated, it can progress to loss of central vision and blindness.

Glaucoma is usually, but not always, associated with elevated pressure in the eye (intraocular pressure). Generally, it is this elevated eye pressure that leads to damage of the eye (optic) nerve. In some cases, glaucoma may occur in the presence of normal eye pressure. This form of glaucoma is believed to be caused by poor regulation of blood flow to the optic nerve.

How common is glaucoma?

Worldwide, glaucoma...

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Phospholine Iodide

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Phospholine Iodide®
(echothiophate iodide) for Ophthalmic Solution

DRUG DESCRIPTION

Chemical name: (2-mercaptoethyl) trimethylammonium iodide O,O-diethyl phosphorothioate

Structural formula

C₉H₂₃INO₃PS M.W 383.23

Echothiophate iodide for ophthalmic solution occurs as a white, crystalline, water-soluble, hygroscopic solid having a slight mercaptan-like odor. When freeze-dried in the presence of potassium acetate, the mixture appears as a white amorphous deposit on the walls of the bottle.

Each package contains materials for dispensing 5 mL of eyedrops: (1) bottle containing sterile echothiophate iodide for ophthalmic solution in one of four potencies [1.5 mg (0.03%), 3 mg (0.06%), 6.25 mg (0.125%), or 12.5 mg (0.25%)] as indicated on the label, with 40 mg potassium acetate in each case. Sodium hydroxide or acetic acid may have been incorporated to adjust pH during manufacturing. (2) a 5 mL bottle of sterile diluent containing chlorobutanol (chloral derivative), 0.55%; mannitol, 1.2%; boric acid, 0.06%; and sodium phosphate, 0.026%. (3) sterilized dropper.

What are the possible side effects of echothiophate iodide ophthalmic (Phospholine Iodide)?

Contact your doctor immediately if you notice any decrease in vision or an increase in "floaters" in your visual field. Rarely, echothiophate iodide ophthalmic may cause retinal detachment. Retinal detachment can lead to blind spots, floaters in your visual field, and even blindness. Your doctor will want to check your retina before you use this medicine to determine if you have an increased risk of retinal detachment.

If you experience any of the following serious side effects, stop using echothiophate iodide...

Read All Potential Side Effects and See Pictures of Phospholine Iodide »

What are the precautions when taking echothiophate iodide for ophthalmic solution (Phospholine Iodide)?

Before using echothiophate, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, epilepsy, other eye problems (e.g., iritis, uveitis, detached retina), heart disease (e.g., heart failure, recent heart attack), low or high blood pressure, myasthenia gravis, overactive thyroid (hyperthyroidism), Parkinsonism, stomach/intestinal problems (e.g., ulcers, spasms), certain urinary problems (e.g., blockage).

After you apply echothiophate, your vision may become temporarily blurred or unstable....

Read All Potential Precautions of Phospholine Iodide »

Last reviewed on RxList: 12/9/2008
This monograph has been modified to include the generic and brand name in many instances.