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Phospholine Iodide

Phospholine Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 4/21/2016

Phospholine Iodide (echothiophate iodide) for Ophthalmic Solution is a cholinesterase inhibitor that works by causing the pupil to shrink, decreasing the amount of fluid within the eye, and affecting certain eye muscles and is used to treat glaucoma by lowering the pressure inside the eye. Phospholine Iodide is also used to treat certain eye disorders involving eye accommodation (focusing). Common side effects of Phospholine Iodide include:

  • temporary irritation/burning/stinging of the eye
  • eye redness or tearing
  • temporary blurred vision
  • eyelid muscle twitching
  • poor vision in dim light
  • headache
  • headache, or
  • brow ache

The recommended dose of Phospholine Iodide for ophthalmic solution 0.03% is to instill into the affected eye(s) twice a day, just before retiring and in the morning. Phospholine Iodide may interact with other eye medications. Organophosphates may increase the effects of Phospholine Iodide. Gardeners, organophosphate plant or warehouse workers, or farmers may be exposed to organophosphates. Follow directions of your doctor and workplace safety guides regarding respiratory masks and washing and changing of clothes. Tell your doctor all medications and supplements you use. During pregnancy, Phospholine Iodide should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Phospholine Iodide (echothiophate iodide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Phospholine in Detail - Patient Information: Side Effects

Contact your doctor immediately if you notice any decrease in vision or an increase in "floaters" in your visual field. Rarely, echothiophate iodide ophthalmic may cause retinal detachment. Retinal detachment can lead to blind spots, floaters in your visual field, and even blindness. Your doctor will want to check your retina before you use this medicine to determine if you have an increased risk of retinal detachment.

If you experience any of the following serious side effects, stop using echothiophate iodide ophthalmic and seek emergency medical attention:

  • an allergic reaction (shortness of breath; swelling of the lips, face, or tongue; or hives);
  • abdominal cramps or diarrhea;
  • watering mouth;
  • excessive sweating;
  • urinary incontinence;
  • muscle weakness;
  • difficulty breathing; or
  • an irregular heart beat.

Other, less serious side effects may be more likely to occur. Continue to use echothiophate iodide ophthalmic and talk to your doctor if you experience

  • burning, stinging, red, or tearing eyes;
  • eyelid muscle twitches;
  • headache or brow ache; or
  • decreased vision in poor light.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Phospholine (Echothiophate Iodide for Ophthalmic Solution)

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Phospholine Overview - Patient Information: Side Effects

SIDE EFFECTS: Temporary irritation/burning/stinging of the eye, temporary blurred vision, eyelid muscle twitching, poor vision in dim light, headache, or brow ache may occur. If any of these effects persist or worsen, contact your doctor or pharmacist promptly. (See also Precautions section.)

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: eye pain, flushing, diarrhea, nausea, irregular heartbeat, stomach/abdominal pain or cramps, increased saliva, increased urination, unusual sweating, vision changes.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Read the entire patient information overview for Phospholine (Echothiophate Iodide for Ophthalmic Solution)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Phospholine FDA Prescribing Information: Side Effects
(Adverse Reactions)


  1. Although the relationship, if any, of retinal detachment to the administration of echothiophate iodide for ophthalmic solution has not been established, retinal detachment has been reported in a few cases during the use of echothiophate iodide for ophthalmic solution in adult patients without a previous history of this disorder.
  2. Stinging, burning, lacrimation, lid muscle twitching, conjunctival and ciliary redness, browache, induced myopia with visual blurring may occur.
  3. Activation of latent iritis or uveitis may occur.
  4. Iris cysts may form, and if treatment is continued, may enlarge and obscure vision. This occurrence is more frequent in children. The cysts usually shrink upon discontinuance of the medication, reduction in strength of the drops or frequency of instillation. Rarely, they may rupture or break free into the aqueous. Regular examinations are advisable when the drug is being prescribed for the treatment of accommodative esotropia.
  5. Prolonged use may cause conjunctival thickening, obstruction of nasolacrimal canals.
  6. Lens opacities occurring in patients under treatment for glaucoma with echothiophate iodide for ophthalmic solution have been reported and similar changes have been produced experimentally in normal monkeys. Routine examinations should accompany clinical use of the drug.
  7. Paradoxical increase in intraocular pressure may follow anticholinesterase instillation. This may be alleviated by prescribing a sympathomimetic mydriatic such as phenylephrine.
  8. Cardiac irregularities.

Read the entire FDA prescribing information for Phospholine (Echothiophate Iodide for Ophthalmic Solution)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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