home > drugs a-z list > physostigmine salicylate (physostigmine salicylate (injection)) drug center > physostigmine salicylate (physostigmine salicylate (injection)) drug - overdosage and contraindications

Can cause a cholinergic crisis. Appropriate antidote is atropine sulfate.

Physostigmine Salicylate (physostigmine salicylate (injection)) Injection should not be used in the presence of asthma, gangrene, diabetes, cardiovascular disease, mechanical obstruction of the intestine or urogenital tract or any vagotonic state, and in patients receiving choline esters and depolarizing neuromuscular blocking agents (decamethonium, succinylcholine).

For post-anesthesia, the concomitant use of atropine with physostigmine salicylate (physostigmine salicylate (injection)) is not recommended, since the atropine antagonizes the action of physostigmine.

Last reviewed on RxList: 11/10/2008
This monograph has been modified to include the generic and brand name in many instances.