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DOSAGE AND ADMINISTRATION
Vasopressin may be administered intramuscularly or subcutaneously.
Ten units of vssopressin (0.5mL) will usually elicit full physiologic response in adult patients: 5units will be adequate in many cases. Vasopressin should be given intramuscularly at three-or four-hour intervals as needed. The dosage should be proportionately reduced for children.(For an additional discussion of dosage, consult the sections below.)
When determining the dose of vasopressin for a given case, the following should be kept in mind.
It is particularly desirable to give a dose not much larger than is just sufficient to elicit the desired physiologic response. Excessive doses may cause undesirable side effects - blanching of the skin, abdominal cramps, nausea, which, though not serious, may be alarming to the patient. Spontaneous recovery from such side effects occurs in a few minutes. It has been found that one or two glasses of water given at the time vasopressin is administered reduce such symptoms.
Abdominal Distention: In the average postoperetive adult patient, give 5 units (0.25 mL) initially, increase to 10 units (0.5mL) at subsequent injections if necessary. It is recommended that vasopressin be given intramuscularly and that injections be repeated at three-or four-hour intervals as required. Dosage to be reduced proportionately for children.
Abdominal Roentgenography: For the average case, two injections of 10 units each (0.5 mL) are suggested . These should be given two hours and one-half hour, respectively, before films are exposed. Many roentgenologists advise giving an enema prior to the first dose of vasopressin.
Diabetes Insipidus: Vasopressin may be given by injection or administered intranasally on cotton pledgets, by nasal spray, or by dropper. The dose by injection is 5 to 10 units (0.25 to 0.5mL) repeated two or three times daily as needed. When vasopressin is administered intranasally by spray or on pledgets, the dosage and interval between treatments must be determined for each patient.
Perenteral drug products should be inspected visually for particulate matter and discoloration prior to use, whenever solution and container permit.
Vasopressin Injection, USP 20units/mL is supplied as follows:
|NDC0517- 0510- 25||10 units per 0.5 mL multiple dose vial||Boxes of 25|
|NDC0517- 1020- 25||20 units per 1mL multiple dose vial||Boxes of 25|
|NDC0517- 0410- 10||200 units per 10 mL multiple dose vial||Boxes of 10|
Store at controlled room temperature 15°-30° C (59°-86° F).This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 12/8/2004
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