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Plavix

Heart attack facts

  • A heart attack results when a blood clot completely obstructs a coronary artery supplying blood to the heart muscle and heart muscle dies.
  • The blood clot that causes the heart attack usually forms at the site of rupture of an atherosclerotic, cholesterol plaque on the inner wall of a coronary artery.
  • The most common symptom of heart attack is chest pain.
  • The most common complications of a heart attack are heart failure and ventricular fibrillation.
  • The risk factors for atherosclerosis and heart attack include elevated cholesterol levels, increased blood pressure, tobacco use, diabetes, male gender, and a family history of heart attacks at an early age.
  • Heart attacks are diagnosed with electrocardiograms and measurement of cardiac enzymes in blood.
  • Early reopening of blocked coronary arteries reduces the amount of damage to the heart and im...

Plavix

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OVERDOSE

Platelet inhibition by Plavix is irreversible and will last for the life of the platelet. Overdose following clopidogrel administration may result in bleeding complications. A single oral dose of clopidogrel at 1500 or 2000 mg/kg was lethal to mice and to rats and at 3000 mg/kg to baboons. Symptoms of acute toxicity were vomiting, prostration, difficult breathing, and gastrointestinal hemorrhage in animals.

Based on biological plausibility, platelet transfusion may restore clotting ability.

CONTRAINDICATIONS

Active Bleeding

Plavix is contraindicated in patients with active pathological bleeding such as peptic ulcer or intracranial hemorrhage.

Hypersensitivity

Plavix is contraindicated in patients with hypersensitivity (e.g., anaphylaxis) to clopidogrel or any component of the product [see ADVERSE REACTIONS].

Last reviewed on RxList: 1/12/2012
This monograph has been modified to include the generic and brand name in many instances.

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