"Dec. 17, 2010 -- The FDA has rejected Brilinta, AstraZeneca's new blood thinner, because U.S. and Canadian patients did not benefit from the drug in a pivotal clinical trial.
Overall, the multinational study found that Brilinta worked b"...
Platelet inhibition by Plavix is irreversible and will last for the life of the platelet. Overdose following clopidogrel administration may result in bleeding complications. A single oral dose of clopidogrel at 1500 or 2000 mg/kg was lethal to mice and to rats and at 3000 mg/kg to baboons. Symptoms of acute toxicity were vomiting, prostration, difficult breathing, and gastrointestinal hemorrhage in animals.
Based on biological plausibility, platelet transfusion may restore clotting ability.
Last reviewed on RxList: 12/30/2013
This monograph has been modified to include the generic and brand name in many instances.
Additional Plavix Information
Report Problems to the Food and Drug Administration
Get the latest treatment options.