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PLETAL is indicated for the reduction of symptoms of intermittent claudication, as demonstrated by an increased walking distance.
DOSAGE AND ADMINISTRATION
The recommended dosage of PLETAL is 100 mg twice daily taken at least half an hour before or two hours after breakfast and dinner.
Patients may respond as early as 2 to 4 weeks after the initiation of therapy, but treatment for up to 12 weeks may be needed before a beneficial effect is experienced. If symptoms are unimproved after 3 months, discontinue PLETAL.
Dose Reduction With CYP3A4 And CYP2C19 Inhibitors
Reduce dose to 50 mg twice daily when coadministered with strong or moderate inhibitors of CYP3A4 (e.g., ketoconazole, itraconazole, erythromycin, and diltiazem) or inhibitors of CYP2C19 (e.g., ticlopidine, fluconazole, and omeprazole)[see DRUG INTERACTIONS]
Dosage Forms And Strengths
PLETAL is available as 50 mg triangular and 100 mg round, white debossed tablets.
Storage And Handling
PLETAL is supplied as 50 mg and 100 mg tablets.
The 50 mg tablets are white, triangular, debossed with PLETAL 50, and provided in bottles of 60 tablets (NDC 59148-003-16).
The 100 mg tablets are white, round, debossed with PLETAL 100, and provided in bottles of 60 tablets (NDC 59148-002-16).
Storage And Handling
Store PLETAL tablets at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [See USP Controlled Room Temperature].
Manufactured by: OTSUKA PHARMACEUTICAL CO., LTD. Tokushima 771-0182, Japan. Revised: Jan 2016This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 9/26/2016
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