Brand Names: Pletal

Generic Name: cilostazol (Pronunciation: sil OS tah zol)

• What is cilostazol (Pletal)?
• What are the possible side effects of cilostazol (Pletal)?
• What is the most important information I should know about cilostazol (Pletal)?
• What should I discuss with my healthcare provider before taking cilostazol (Pletal)?
• How should I take cilostazol (Pletal)?
• What happens if I miss a dose (Pletal)?
• What happens if I overdose (Pletal)?
• What should I avoid while taking cilostazol (Pletal)?
• What other drugs will affect cilostazol (Pletal)?
• Where can I get more information?

What is cilostazol (Pletal)?

Cilostazol widens arteries that supply blood to the legs. Cilostazol also improves circulation by keeping platelets in the blood from sticking together and clotting.

Cilostazol is used to treat the symptoms of intermittent claudication. This condition causes reduced blood flow to the legs, leading to pain while walking. Cilostazol improves your ability to walk longer distances without pain.

Cilostazol may also be used for other purposes not listed in this medication guide.

Cilostazol 100 mg-APO

round, white, imprinted with APO, CIL 100

Cilostazol 100 mg-MYL

round, white, imprinted with M C42

Cilostazol 100 mg-ROX

round, white, imprinted with 54 757

Cilostazol 100 mg-TEV

round, white, imprinted with 7231, 9 3

Cilostazol 50 mg-AND

round, white, imprinted with G, CL 50

Cilostazol 50 mg-APO

round, white, imprinted with APO, CIL 50

Cilostazol 50 mg-MYL

round, white, imprinted with M C41

Cilostazol 50 mg-ROX

round, white, imprinted with 54 521

Cilostazol 50 mg-SAN

round, white, imprinted with E 123

Cilostazol 50 mg-TEV

rectangular, white, imprinted with 7230, 9 3

What are the possible side effects of cilostazol (Pletal)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• severe headache;
• bloody urine, painful urination;
• fever, chills, body aches, flu symptoms;
• chest pain;
• feeling short of breath, even with mild exertion; or
• swelling of your ankles or feet.

Less serious side effects may include:

• fast or pounding heartbeats;
• diarrhea, vomiting;
• weakness, dizziness;
• leg cramps;
• numbness or tingling;
• joint pain; or
• cough, runny or stuffy nose.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about cilostazol (Pletal)?

Do not take cilostazol if you have congestive heart failure. Cilostazol can make this condition worse.

It may take up to 12 weeks of using cilostazol before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 4 weeks of treatment.

Grapefruit and grapefruit juice may interact with cilostazol. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Take cilostazol on an empty stomach, at least 30 minutes before or 2 hours after food.