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Podocon-25 Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 11/5/2015

Podocon-25 (25% podophyllin in benzoin tincture) is a skin medication made from a powdered mixture of extracts from a plant called Mandrake, or May apple, used to treat genital warts on the outside of the penis or vagina, or on the skin between the rectum and the genitals. Podocon-25 may be available in generic form. Common side effects of Podocon-25 include mild bloating, constipation, application site reactions (slight stinging, pain, numbness, tingling, or burning), or fever.

Podocon-25 resin is applied only by a physician, who will apply the proper dose to the affected area. It is not likely other drugs you take orally or inject will have an effect on topically applied Podocon-25 resin. But many drugs can interact with each other. Tell your doctor all prescription and over-the-counter medications and supplements you use. Podocon-25 is not recommended for use during pregnancy. It can cause birth defects. Do not use this drug if you are pregnant. Tell your doctor if you become pregnant during treatment. Use birth control while using this medication. It is unknown if this medication passes into breast milk or if it could harm a nursing baby. Do not use this medication if you are breast-feeding.

Our Podocon-25 (25% podophyllin in benzoin tincture) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Podocon-25 in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • severe burning, stinging, itching, redness, swelling, or skin changes where the medicine was applied;
  • numbness, burning, pain, or tingly feeling;
  • easy bruising or bleeding, weakness;
  • fever; or
  • severe constipation or stomach cramps.

Less serious side effects may include:

  • mild bloating, constipation; or
  • slight stinging or pain where the medicine was applied.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Podocon-25 (Podophyllin)

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Podocon-25 FDA Prescribing Information: Side Effects
(Adverse Reactions)


The use of topical podophyllin has been known to result in paresthesia, polyneuritis, paralytic ileus, pyrexia, leukopenia, thrombocytopenia, coma and death(5).

Read the entire FDA prescribing information for Podocon-25 (Podophyllin)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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