July 26, 2016

Podophyllum

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How does Podophyllum work?

Podophyllum can stop cell duplication and new growth. It can also have laxative effects.

Are there safety concerns?

When applied by medical professionals in low concentration to unbroken skin, podophyllum is POSSIBLY SAFE for most people. It should be washed off within 4 to 6 hours. Podophyllum should not be used in higher concentrations or over large areas of the body. It is absorbed through the skin and can cause the same serious harmful effects as taking podophyllum by mouth. Podophyllotoxin, a chemical found in podophyllum, is safer and has largely replaced podophyllum as a treatment.

Podophyllum is LIKELY UNSAFE when taken by mouth or applied to the skin in higher concentrations over large areas of the body. It is poisonous. It may cause nausea, vomiting, dizziness, headache, spasms, fever, visual changes and hallucinations, low blood pressure, bone marrow problems, paralysis, coma, liver problems, and kidney problems. It can take up to 13 hours for symptoms of poisoning to appear. Some deaths after taking podophyllum by mouth or applying it to the skin in large amounts have been reported. Podophyllum poisoning has been successfully treated in some cases by using activated charcoal.

Special Precautions & Warnings:

Pregnancy and breast-feeding:It is LIKELY UNSAFE to take podophyllum by mouth or apply it to your skin if you are pregnant. There have been reports of death and multiple birth defects in babies whose mothers used podophyllum during pregnancy.

It is also LIKELY UNSAFE to use podophyllum if you are breast-feeding. The poisons in podophyllum can endanger you and your nursing baby.

Dosing considerations for Podophyllum.

The following doses have been studied in scientific research:

APPLIED TO THE SKIN:
  • Podophyllum should not be used for self-treatment. Covering too much skin with podophyllum or applying it to broken skin increases the chance of getting poisoned. It's safer to use podophyllotoxin (one of the chemicals in podophyllum).
  • For genital warts caused by human papilloma virus (HPV): A 0.5% podophyllotoxin gel is applied twice daily for three days in a row and repeated for two to four cycles. Podophyllotoxin is a chemical taken from podophyllum. Podophyllotoxin (podofilox, Condylox) is an FDA-approved drug. Podophyllotoxin might be more effective than podophyllum and is less toxic.

Therapeutic Research Faculty copyright

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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