"For nearly a century, bacteria-fighting drugs known as antibiotics have helped to control and destroy many of the harmful bacteria that can make us sick. But in recent decades, antibiotics have been losing their punch against some types of bac"...
Polymyxin B (polymyxin b sulfate) sulfate has a bactericidal action against almost all gram-negative bacilli except the Proteus group. Polymyxins increase the permeability of bacterial cell wall membranes. All gram-positive bacteria, fungi, and the gram-negative cocci, N gonorrhoeae and N meningitidis, are resistant.
Susceptibility plate testing: If the Kirby-Bauer method of disc susceptibility testing is used, a 300-unit polymyxin B (polymyxin b sulfate) disc should give a zone of over 11 mm when tested against a polymyxin B susceptible bacterial strain.
Polymyxin B (polymyxin b sulfate) sulfate is not absorbed from the normal alimentary tract.Since the drug loses 50 percent of its activity in the presence of serum, active blood levels are low. Repeated injections may give a cumulative effect. Levels tend to be higher in infants and children.The drug is excreted slowly by the kidneys.Tissue diffusion is poor and the drug does not pass the blood brain barrier into the cerebrospinal fluid. In therapeutic dosage, polymyxin B (polymyxin b sulfate) sulfate causes some nephrotoxicity with tubule damage to a slight degree.
Last reviewed on RxList: 9/10/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Polymyxin B Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Find out what women really need.