July 27, 2016
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Polymyxin B

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Polymyxin B

Polymyxin B Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 9/18/2015

Polymyxin B (polymyxin b sulfate) is an antibiotic used to treat bacterial infections such as urinary tract infections, meningitis, blood infections, and eye infections. Polymyxin B is available in generic form. Common side effects of Polymyxin B include pain, redness, and swelling at the injection site, or temporary eye stinging/burning/redness/itchiness or temporary blurred vision if used as eye drops. Contact your doctor if you experience serious side effects of Polymyxin B including flushing, dizziness, drowsiness, fever, headache, numbness or tingling in the hands or feet, back pain, stiff neck, unsteadiness, and rash.

Polymyxin B dose is determined by a doctor, based on the condition being treated. It may be injected into a vein, muscle, or the spinal fluid or into the area around the eye (subconjunctival sac). It can also be prepared as eye drops. Polymyxin B may interact with other drugs that can harm the kidneys or nerves (e.g., cisplatin, colistin, high-dose aspirin, aminoglycosides such as amikacin, gentamicin, tobramycin, nonsteroidal anti-inflammatory drugs-NSAIDs such as ibuprofen or naproxen). Tell your doctor all medications you are taking. During pregnancy, Polymyxin B should be used only when prescribed. It is unknown if this medication passes into breast milk when used in the eye. It is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Our Polymyxin B (polymyxin b sulfate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Prescribing information?

The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.

Polymyxin B FDA Prescribing Information: Side Effects
(Adverse Reactions)


See WARNING box.

Nephrotoxic reactions: Albuminuria, cylin-duria, azotemia, and rising blood levels without any increase in dosage.

Neurotoxic reactions: Facial flushing, dizziness progressing to ataxia, drowsiness, peripheral paresthesias (circumoral and stocking glove), apnea due to concurrent use of curariform muscle relaxants, other neurotoxic drugs or inadvertent overdosage, and signs of meningeal irritation with intrathecal administration, e.g., fever, headache, stiff neck and increased cell count and protein cerebrospinal fluid.

Other reactions occasionally reported: Drug fever, urticarial rash, pain (severe) at intramuscular injection sites, and thrombophlebitis at intravenous injection sites.

Read the entire FDA prescribing information for Polymyxin B (Polymyxin B Sulfate)

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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