Pomegranate

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Are there any interactions with medications?



Carbamazepine (Tegretol)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Carbamazepine (Tegretol) is broken down by the body. Drinking pomegranate juice might decrease how fast the body breaks down carbamazepine (Tegretol). This might increase the effects and side effects of carbamazepine (Tegretol).



Medications changed by the body (Cytochrome P450 2C9 (CYP2C9) substrates
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the body. Pomegranate might decrease how quickly the body breaks down some medications. Taking pomegranate along with some medications that are changed by the body can increase the effects and side effects of your medication. Before taking pomegranate, talk to your healthcare provider if you take any medications that are changed by the body.

Some medications that are changed by the body include celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), and S-warfarin (Coumadin).



Medications changed by the body (Cytochrome P450 2D6 (CYP2D6) substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the body. Pomegranate might decrease how quickly the body breaks down some medications. Taking pomegranate along with some medications that are changed by the body can increase the effects and side effects of your medication. Before taking pomegranate, talk to your healthcare provider if you take any medications that are changed by the body.

Some medications that are changed by the body include amitriptyline (Elavil), codeine, desipramine (Norpramin), flecainide (Tambocor), fluoxetine (Prozac), ondansetron (Zofran), tramadol (Ultram), and others.



Medications changed by the body (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the body. Drinking pomegranate juice might decrease how quickly the body breaks down some medications. Drinking pomegranate juice and taking some medications that are broken down by the body can increase the effects and side effects of some medications. Before drinking pomegranate juice, talk to your healthcare provider if you are taking any medications that are changed by the body.

Some medications changed by the body include amlodipine (Norvasc), diltiazem (Cardizem), verapamil (Verelan, Calan, others), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), saquinavir (Invirase), alfentanil (Alfenta), fentanyl (Sublimaze), midazolam (Versed), ondansetron (Zofran), propranolol (Inderal), and many others.



Medications for high blood pressure (ACE inhibitors)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Pomegranate juice seems to lower blood pressure. Taking pomegranate juice along with medications for high blood pressure might cause your blood pressure to go too low.

Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others.



Medications for high blood pressure (Antihypertensive drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Pomegranate seems to lower blood pressure. Taking pomegranate along with medications for high blood pressure might cause your blood pressure to go too low.

Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.



Rosuvastatin (Crestor)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Rosuvastatin (Crestor) is broken down by the body in the liver. Drinking pomegranate juice might decrease how quickly the liver breaks down rosuvastatin (Crestor). This might increase the effects and side effects of rosuvastatin (Crestor).



Tolbutamide (Orinase)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Tolbutamide (Orinase) is broken down by the body. Drinking pomegranate juice might decrease how fast the body breaks down tolbutamide (Orinase). This might increase the effects and side effects of tolbutamide (Orinase).



Warfarin (Coumadin)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Warfarin (Coumadin) is broken down by the body. Drinking pomegranate juice might decrease how fast the body breaks down warfarin (Coumadin). This might increase the effects and side effects of warfarin (Coumadin).

Dosing considerations for Pomegranate.

The appropriate dose of pomegranate depends on several factors such as the user's age, health, and several other conditions. At this time, there is not enough scientific information to determine an appropriate range of doses for pomegranate. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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