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Potassium Chloride in Lactated Ringer's and Dextrose

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Potassium Chloride in Lactated Ringer's and 5% Dextrose Injection

Potassium Chloride in Lactated Ringer's and 5% Dextrose
Injection, USP in Plastic Container

VIAFLEX Plus Container

DRUG DESCRIPTION

Potassium Chloride in Lactated Ringer's and 5% Dextrose Injection, USP is a sterile, nonpyrogenic solution for fluid and electrolyte replenishment and caloric supply in a single dose container for intravenous administration. It contains no antimicrobial agents. Composition, osmolarity, pH, ionic concentration and caloric content are shown below:

Potassium Chloride in Lactated Ringer's and 5% Dextrose Injection,USP Size (mL) Composition (g/L) *Osmolarity (mOsmol/L) (calc.)
mEq Potassium added ** Dextrose Hydrous, USP Sodium Chloride, USP (NaCl) Sodium Lactate, (C3H5NaO3) Potassium Chloride, USP (KCl) Calcium Chloride, USP (CaCl2·2H20)
20 mEq 1000 50 6 3.1 1.79 0.2 565
40 mEq 1000 50 6 3.1 3.28 0.2 605
*Normal physiologic osmolarity range is approximately 280 to 310 mOsmol/L. Administration of substantially hypertonic solutions ( ≥ 600 mOsmol/L) may cause vein damage.

  pH Ionic Concentration (mEq/L) Caloric Content (kcal/L)
Potassium Chloride in Lactated Ringer's and 5% Dextrose Injection, USP Sodium Potassium Calcium Chloride Lactate
mEq Potassium added
20 mEq 5.0
(3.5 to 6.5)
130 24 3 129 28 170
40 mEq 5.0
(3.5 to 6.5)
130 44 3 149 28 170
** The chemical structure for Dextrose Hydrous, USP is shown below:

Dextrose Hydrous Structural Formula Illustration

The VIAFLEX Plus plastic container is fabricated from a specially formulated polyvinyl chloride (PL 146 Plastic). VIAFLEX Plus on the container indicates the presence of a drug additive in a drug vehicle. The VIAFLEX Plus plastic container system utilizes the same container as the VIAFLEX plastic container system. The amount of water that can permeate from inside the container into the overwrap is insufficient to affect the solution significantly. Solutions in contact with the plastic container can leach out certain of its chemical components in very small amounts within the expiration period, e.g., di-2-ethylhexyl phthalate (DEHP), up to 5 parts per million. However, the safety of the plastic has been confirmed in tests in animals according to USP biological tests for plastic containers as well as by tissue culture toxicity studies.

Last reviewed on RxList: 9/29/2008
This monograph has been modified to include the generic and brand name in many instances.

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