""Nonfunctional" adrenal tumors may be anything but, new research suggests.
In a study published online August 2, 2016 in the Annals of Internal Medicine, Diana Lopez, MD, of Brigham and Women's Hospital and Harvard Medical Sc"...
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
REPAGLINIDE/METFORMIN - ORAL
COMMON BRAND NAME(S): Prandimet
WARNING: Metformin can rarely cause a serious (sometimes fatal) condition called lactic acidosis. Stop taking this medication and seek immediate medical attention if you develop any of the following symptoms of lactic acidosis: unusual tiredness, severe drowsiness, chills, blue/cold skin, muscle pain, fast/difficult breathing, unusually slow/irregular heartbeat.
Lactic acidosis is more likely to occur in patients who have certain medical conditions, including kidney or liver disease, heavy alcohol use, loss of too much body water (dehydration), recent surgery, conditions that may cause a low oxygen blood level or poor circulation (such as severe congestive heart failure, recent heart attack, recent stroke), or a serious infection. Tell your doctor immediately if any of these conditions occur or if you notice a big change in your overall health. You may need to temporarily stop this medication. Also tell your doctor that you are taking this medication before having surgery or any X-ray/scanning procedures that require an injectable iodinated contrast drug. Consult your doctor for further instructions.
Older adults, especially those older than 80 years who have not had kidney tests, may be at greater risk for side effects such as lactic acidosis while using this drug. (See also Side Effects and Precautions sections.)
USES: This anti-diabetic medication is a combination of 2 drugs (repaglinide and metformin). It is used along with a diet and exercise program to control high blood sugar in patients with type 2 diabetes.
Repaglinide works by stimulating the release of your body's natural insulin. Metformin is a biguanide and works by decreasing the amount of sugar that your liver makes and that your stomach/intestines absorb. Both of these medications work by helping to restore your body's proper response to the insulin you naturally produce.
Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.
HOW TO USE: Take this medication by mouth 15 minutes before a meal, usually 2-3 times a day or as directed by your doctor. Take this drug no earlier than 30 minutes before the meal. You may also take it just before the meal if necessary. Do not take a dose of medication if you are skipping a meal. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor.
The dosage is based on your medical condition and response to treatment. Your doctor will adjust your dose based on your blood sugar levels to find the best dose for you. Your doctor may start you on a lower dose of metformin and gradually increase the dose to lower the chance of side effects such as upset stomach. Follow your doctor's directions carefully.
If you are changing from a different anti-diabetic drug (such as chlorpropamide), follow your doctor's directions carefully for stopping the old drug and starting this combination medication.
Use this medication regularly in order to get the most benefit from it. Carefully follow the medication treatment plan, meal plan, and exercise program your doctor has recommended.
Check your blood sugar regularly as directed by your doctor. Keep track of the results and share them with your doctor. Tell your doctor if your blood sugar measurements are too high or too low. Your treatment plan may need to be changed.
Additional Prandimet Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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