"Miriam E. Tucker
Medscape Medical News
The US Food and Drug Administration has approved the empagliflozin/linagliptin combination Glyxambi (Boehringer Ingelheim/Eli Lilly) as adjunctive treatment to diet and "...
Prandimet Patient Information including If I Miss a Dose
In this Article
- What is metformin and repaglinide (Prandimet)?
- What are the possible side effects of metformin and repaglinide (Prandimet)?
- What is the most important information I should know about metformin and repaglinide (Prandimet)?
- What should I discuss with my doctor before taking metformin and repaglinide (Prandimet)?
- How should I take metformin and repaglinide (Prandimet)?
- What happens if I miss a dose (Prandimet)?
- What happens if I overdose (Prandimet)?
- What should I avoid while taking metformin and repaglinide (Prandimet)?
- What other drugs will affect metformin and repaglinide (Prandimet)?
- Where can I get more information?
What happens if I miss a dose (Prandimet)?
Take the missed dose as soon as you remember, but only if you are getting ready to eat a meal. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Prandimet)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A metformin and repaglinide overdose can cause life-threatening hypoglycemia. Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).
Overdose may also cause a life-threatening condition called lactic acidosis. Get emergency medical help if you have any of these symptoms of lactic acidosis: weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting.
What should I avoid while taking metformin and repaglinide (Prandimet)?
Avoid drinking alcohol. It lowers blood sugar and may increase your risk of lactic acidosis while taking metformin and repaglinide.
What other drugs will affect metformin and repaglinide (Prandimet)?
Using beta-blockers such as atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), and propranolol (Inderal, InnoPran) can make it harder for you to tell when you have low blood sugar. Tell your doctor if you use any heart or blood pressure medication.
Tell your doctor about all other medicines you use, especially:
- anastrozole (Arimidex);
- cimetidine (Tagamet) or ranitidine (Zantac);
- conivaptan (Vaprisol);
- cyclosporine (Gengraf, Neoral, Sandimmune);
- deferasirox (Exjade);
- imatinib (Gleevec);
- isoniazid (for treating tuberculosis);
- montelukast (Singulair);
- morphine (MS Contin, Kadian, Oramorph);
- nefazodone (an antidepressant);
- quinine (Qualaquin);
- vancomycin (Vancocin);
- an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifampin (Rifater, Rifadin, Rifamate), or telithromycin (Ketek);
- antifungal medication such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), posaconazole (Noxafil), or voriconazole (Vfend);
- cholesterol-lowering medication such as ezetimibe (Vytorin, Zetia) or gemfibrozil (Lopid);
- a diuretic (water pill), such as amiloride (Midamor), furosemide (Lasix), or triamterene (Dyrenium);
- heart or blood pressure medication such as digoxin (digitalis, Lanoxin), nicardipine (Cardene), nifedipine (Nifedical, Procardia), procainamide (Procan, Procanbid, Pronestyl), or quinidine (Quin-G);
- the hepatitis C medications boceprevir (Victrelis) or telaprevir (Incivek);
- HIV/AIDS medication such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, Kaletra), or saquinavir (Invirase);
- a non-steroidal anti-inflammatory drug (NSAID) such as flurbiprofen (Ansaid), ibuprofen (Advil, Motrin), indomethacin (Indocin), mefenamic acid (Ponstel), or piroxicam (Feldene);
- other diabetes medications such as pioglitazone (Actos, Duetact, Actoplus Met) or tolbutamide (Orinase); or
- a sulfa drug, such as sulfisoxazole (Pediazole, and others) or trimethoprim (Bactrim, Primsol, Proloprim, Septra, Cotrim).
This list is not complete and other drugs may interact with metformin and repaglinide. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about metformin and repaglinide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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Additional Prandimet Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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