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Precedex

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Precedex

Indications
Dosage
How Supplied

INDICATIONS

Intensive Care Unit Sedation

Precedex™ is indicated for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting. Precedex should be administered by continuous infusion not to exceed 24 hours.

Precedex has been continuously infused in mechanically ventilated patients prior to extubation, during extubation, and post-extubation. It is not necessary to discontinue Precedex prior to extubation.

Procedural Sedation

Precedex is indicated for sedation of non-intubated patients prior to and/or during surgical and other procedures.

DOSAGE AND ADMINISTRATION

Dosing Guidelines

Precedex dosing should be individualized and titrated to desired clinical response.

Precedex is not indicated for infusions lasting longer than 24 hours.

Precedex should be administered using a controlled infusion device.

Dosage Information

Table 1: Dosage Information

INDICATION DOSAGE AND ADMINISTRATION
Initiation of Intensive Care Unit Sedation

For adult patients: a loading infusion of one mcg/kg over 10 minutes.
For adult patients being converted from alternate sedative therapy: a loading dose may not be required.
For patients over 65 years of age: a dose reduction should be considered [see Use in Specific Populations].
For adult patients with impaired hepatic-function: a dose reduction should be considered [see Use In Specific Populations,CLINICAL PHARMACOLOGY].

Maintenance of Intensive Care Unit Sedation For adult patients: a maintenance infusion of 0.2 to 0.7 mcg/kg/hour. The rate of the maintenance infusion should be adjusted to achieve the desired level of sedation.
For patients over 65 years of age: a dose reduction should be considered [see Use in Specific Populations].
For adult patients with impaired hepatic function: a dose reduction should be considered [see Use In Specific Populations, CLINICAL PHARMACOLOGY].
Initiation of Procedural Sedation For adult patients: a loading infusion of one mcg/kg over 10 minutes. For less invasive procedures such as ophthalmic surgery, a loading infusion of 0.5 mcg/kg given over 10 minutes may be suitable.
For awake fiberoptic intubation in adult patients: a loading infusion of one mcg/kg over 10 minutes.
For patients over 65 years of age: a loading infusion of 0.5 mcg/kg over 10 minutes [see Use in Specific Populations].
For adult patients with impaired hepatic function: a dose reduction should be considered [see Use In Specific Populations, CLINICAL PHARMACOLOGY].
Maintenance of Procedural Sedation For adult patients: the maintenance infusion is generally initiated at 0.6 mcg/kg/hour and titrated to achieve desired clinical effect with doses ranging from 0.2 to 1 mcg/kg/hour. The rate of the maintenance infusion should be adjusted to achieve the targeted level of sedation.
For awake fiberoptic intubation in adult patients: a maintenance infusion of 0.7 mcg/kg/hour is recommended until the endotracheal tube is secured.
For patients over 65 years of age: a dose reduction should be considered [see Use In Specific Populations].
For adult patients with impaired hepatic function: a dose reduction should be considered [see Use In Specific Populations, CLINICAL PHARMACOLOGY].

Dosage Adjustment

Due to possible pharmacodynamic interactions, a reduction in dosage of Precedex or other concomitant anesthetics, sedatives, hypnotics or opioids may be required when co-administered [see DRUG INTERACTIONS].

Dosage reductions may need to be considered for adult patients with hepatic impairment, and geriatric patients [see WARNINGS AND PRECAUTIONS, Use In Specific Populations, CLINICAL PHARMACOLOGY].

Preparation Of Solution

Strict aseptic technique must always be maintained during handling of Precedex.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

Precedex Injection, 200 mcg/2 mL (100 mcg/mL)

Precedex must be diluted with 0.9% sodium chloride injection to achieve required concentration (4 mcg/mL) prior to administration. Preparation of solutions is the same, whether for the loading dose or maintenance infusion.

To prepare the infusion, withdraw 2 mL of Precedex Injection, and add to 48 mL of 0.9% sodium chloride injection to a total of 50 mL. Shake gently to mix well.

Precedex in 0.9% Sodium Chloride Injection, 200 mcg/50 mL (4 mcg/mL) and 400 mcg/100 mL (4 mcg/mL)

Precedex in 0.9% Sodium Chloride Injection is supplied in glass containers containing a premixed, ready to use dexmedetomidine hydrochloride solution in 0.9% sodium chloride in water. No further dilution of these preparations are necessary.

Administration With Other Fluids

Precedex infusion should not be co-administered through the same intravenous catheter with blood or plasma because physical compatibility has not been established.

Precedex has been shown to be incompatible when administered with the following drugs: amphotericin B, diazepam.

Precedex has been shown to be compatible when administered with the following intravenous fluids:

Compatibility With Natural Rubber

Compatibility studies have demonstrated the potential for absorption of Precedex to some types of natural rubber. Although Precedex is dosed to effect, it is advisable to use administration components made with synthetic or coated natural rubber gaskets.

HOW SUPPLIED

Dosage Forms And Strengths

Precedex Injection

Precedex Injection, 200 mcg/2 mL dexmedetomidine (100 mcg/mL) in a glass vial. To be used after dilution.

Precedex in 0.9% Sodium Chloride Injection

Precedex Injection, 200 mcg dexmedetomidine/50 mL (4 mcg/mL) dexmedetomidine in a 50 mL glass bottle. Ready to use.

Precedex Injection, 400 mcg dexmedetomidine/100 mL (4 mcg/mL) dexmedetomidine in a 100 mL glass bottle. Ready to use.

Storage And Handling

Precedex Injection

Precedex (dexmedetomidine hydrochloride) injection 200 mcg/2 mL (100 mcg/mL) is available in 2 mL clear glass vials. The strength is based on the dexmedetomidine base. Vials are intended for single use only.

NDC No. Container Size
0409-1638-02 Vial 2 mL

Precedex in 0.9% Sodium Chloride Injection

Precedex (dexmedetomidine hydrochloride in 0.9% Sodium Chloride) injection is available as 200 mcg/50 mL (4 mcg/mL) and 400 mcg/100 mL (4 mcg/mL) in 50 mL and 100 mL clear glass bottles, respectively. Containers are intended for single use only.

NDC No. Container Size
0409-1660-50 Bottle 50 mL
0409-1660-10 Bottle 100 mL

Store at controlled room temperature, 25°C (77°F) with excursions allowed from 15 to 30°C (59 to 86°F). [See USP.]

Manufactured and Distributed by: Hospira, Inc., Lake Forest, IL 60045 USA. Licensed from: Orion Corporation, Espoo, Finland EN-3411, Hospira, Inc., Lake Forest, IL 60045 USA. Revised: Dec 2013

Last reviewed on RxList: 12/5/2014
This monograph has been modified to include the generic and brand name in many instances.

Indications
Dosage
How Supplied
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