April 29, 2017
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Pred-G

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Pred-G

PRED-G®
(gentamicin and prednisolone acetate) Ophthalmic Suspension, USP 0.3%/1%  Sterile




DRUG DESCRIPTION

PRED-G®  sterile ophthalmic suspension is a topical anti-inflammatory/anti-infective combination product for ophthalmic use.

Structural Formulae:

Pred-G (gentamicin and prednisolone acetate) Structural Formula Illustration

Chemical Names: Prednisolone acetate: 11ß,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate.

Gentamicin sulfate is the sulfate salt of gentamicin C1, gentamicin C2, and gentamicin C1A  which are produced by the growth of Micromonospora purpurea.

Contains: Actives: Gentamicin sulfate equivalent to 0.3% gentamicin base; prednisolone acetate (microfine suspension) 1%. Preservative: Benzalkonium chloride 0.005%. Inactives: edetate disodium; hypromellose; polyvinyl alcohol 1.4%; polysorbate 80; purified water; sodium chloride; and sodium citrate, dihydrate. May contain sodium hydroxide and/or hydrochloric acid to adjust pH (5.4 to 6.6).

PRED-G®  suspension is formulated with a pH from 5.4 to 6.6 and its osmolality ranges from 260 to 340 mOsm/kg.

What are the possible side effects of gentamicin and prednisolone ophthalmic (Pred-G, Pred-G S.O.P.)?

Serious side effects are not expected with this medication.

Some burning, stinging, irritation, itching, redness, blurred vision, eyelid itching, eyelid swelling, or sensitivity to light may occur.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at...

Read All Potential Side Effects and See Pictures of Pred-G »

What are the precautions when taking gentamicin and prednisolone acetate (Pred-G)?

Before using this medication, tell your doctor or pharmacist if you are allergic to gentamicin or prednisolone; or to aminoglycoside antibiotics (e.g., neomycin, tobramycin); or to corticosteroids (e.g., dexamethasone, hydrocortisone); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems (e.g., glaucoma).

After you apply this drug, your vision may become temporarily unstable. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform...

Read All Potential Precautions of Pred-G »

Last reviewed on RxList: 3/29/2017
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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