"The U.S. Food and Drug Administration today approved Osphena (ospemifene) to treat women experiencing moderate to severe dyspareunia (pain during sexual intercourse), a symptom of vulvar and vaginal atrophy due to menopause.
Prefest Patient Information including If I Miss a Dose
In this Article
- What is estradiol and norgestimate (Prefest)?
- What are the possible side effects of estradiol and norgestimate (Prefest)?
- What is the most important information I should know about estradiol and norgestimate (Prefest)?
- What should I discuss with my healthcare provider before taking estradiol and norgestimate (Prefest)?
- How should I take estradiol and norgestimate (Prefest)?
- What happens if I miss a dose (Prefest)?
- What happens if I overdose (Prefest)?
- What should I avoid while taking estradiol and norgestimate (Prefest)?
- What other drugs will affect estradiol and norgestimate (Prefest)?
- Where can I get more information?
What happens if I miss a dose (Prefest)?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
If you miss 2 doses in a row, take the next tablet in order and keep taking only one pill per day. Call your doctor if you miss more than 2 doses of this medication.
What happens if I overdose (Prefest)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose can cause nausea, vomiting, or vaginal bleeding.
What should I avoid while taking estradiol and norgestimate (Prefest)?
Do not smoke while using this medication. Smoking can increase your risk of blood clots, stroke, or heart attack caused by estradiol and norgestimate.
What other drugs will affect estradiol and norgestimate (Prefest)?
Tell your doctor about all other medicines you use, especially:
- St. John's wort;
- an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), rifapentine (Priftin), or telithromycin (Ketek);
- nefazodone (an antidepressant);
- antifungal medication such as itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), or voriconazole (Vfend);
- a barbiturate such as phenobarbital (Solfoton);
- heart or blood pressure medication such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others;
- HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva, Atripla), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), saquinavir (Invirase), or ritonavir (Norvir, Kaletra); or
- seizure medication such as carbamazepine (Carbatrol, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline).
This list is not complete and other drugs may interact with estradiol and norgestimate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about estradiol and norgestimate.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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Additional Prefest Information
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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