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Prelone Side Effects Center
Medical Editor: John P. Cunha, DO, FACOEP
Prelone (prednisolone syrup) is an adrenocortical steroid used to treat conditions such as arthritis, blood problems, immune system disorders, skin and eye conditions, breathing problems, cancer, and severe allergies. Prelone is available in generic form. Common side effects of Prelone include nausea, stomach pain or upset, bloating, heartburn, increased appetite, headache, dizziness, spinning sensation, menstrual period changes, trouble sleeping (insomnia), mood changes, increased sweating, or acne.
The initial dosage of Prelone Syrup varies from 5 mg to 60 mg per day depending on the disease being treated. Prelone may interact with aldesleukin, other drugs that weaken the immune system (such as azathioprine, cyclosporine, cancer chemotherapy, natalizumab), large doses of aspirin and salicylates, nonsteroidal anti-inflammatory drugs (NSAIDs), mifepristone, amphotericin B, diuretics, antibiotics, blood thinners, antiplatelet drugs, estrogens, azole antifungals, rifamycins, St. John's wort, or drugs used to treat seizures. Tell your doctor all medications and supplements you use. During pregnancy, Prelone should be used only if prescribed. It may rarely harm a fetus. Infants born to mothers who have been using this medication for an extended period of time may have hormone problems. Tell your doctor if you notice symptoms such as persistent nausea/vomiting, severe diarrhea, or weakness in your newborn. Prelone passes into breast milk. However, this drug is unlikely to harm a nursing infant. Consult your doctor before breastfeeding.
Our Prelone (prednisolone syrup) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Patient Information Overview?
A concise overview of the drug for the patient or caregiver from First DataBank.
Prelone Overview - Patient Information: Side Effects
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Because this drug works by weakening the immune system, it may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor immediately if you have any signs of infection (such as cough, sore throat, fever, chills). Use of this medication for prolonged or repeated periods may result in oral thrush or a yeast infection. Contact your doctor if you notice white patches in your mouth or a change in vaginal discharge.
This medication may infrequently make your blood sugar level rise, which can cause or worsen diabetes. Tell your doctor immediately if you develop symptoms of high blood sugar such as increased thirst and urination. If you already have diabetes, be sure to check your blood sugars regularly. Your doctor may need to adjust your diabetes medication, exercise program, or diet.
Tell your doctor immediately if any of these unlikely but serious side effects occur: unusual tiredness, swelling ankles/feet, unusual weight gain, vision problems, easy bruising/bleeding, puffy face, unusual hair growth, mental/mood changes (such as depression, mood swings, agitation), muscle weakness/pain, thinning skin, slow wound healing, bone pain.
This drug may infrequently cause serious (rarely fatal) bleeding from the stomach or intestines. If you notice any of the following unlikely but serious side effects, consult your doctor immediately: black/bloody stools, vomit that looks like coffee grounds, persistent stomach/abdominal pain.
Seek immediate medical attention if any of these rare but serious side effects occur: chest pain, seizures.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire patient information overview for Prelone (Prednisolone (syrup))
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Prelone FDA Prescribing Information: Side Effects
Fluid and Electrolyte Disturbances
- Sodium retention
- Fluid retention
- Congestive heart failure in susceptible patients
- Potassium loss
- Hypokalemic alkalosis
- Muscle weakness
- Steroid myopathy
- Loss of muscle mass
- Vertebral compression fractures
- Aseptic necrosis of femoral and humeral heads
- Pathologic fracture of long bones
- Peptic ulcer with possible perforation and hemorrhage
- Abdominal distention
- Ulcerative esophagitis
- Impaired wound healing
- Thin fragile skin
- Petechiae and ecchymoses
- Facial erythema
- Increased sweating
- May suppress reactions to skin tests
- Increased intracranial pressure with papilledema (pseudo-tumor cerebri) usually after treatment
- Menstrual irregularities
- Development of Cushingoid state
- Suppression of growth in pediatric patients
- Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery or illness
- Decreased carbohydrate tolerance
- Manifestations of latent diabetes mellitus
- Increased requirements for insulin or oral hypoglycemic agents in diabetics
Read the entire FDA prescribing information for Prelone (Prednisolone (syrup))
Additional Prelone Information
- Prelone Drug Interactions Center: prednisolone oral
- Prelone Side Effects Center
- Prelone Overview including Precautions
- Prelone FDA Approved Prescribing Information including Dosage
Prelone - User Reviews
Prelone User Reviews
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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