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What is menopause?

Menopause is defined as the state of an absence of menstrual periods for 12 months. The menopausal transition starts with varying menstrual cycle length and ends with the final menstrual period. Perimenopause means "the time around menopause" and is often used to refer to the menopausal transitional period. It is not officially a medical term, but is sometimes used to explain certain aspects of the menopause transition in lay terms. Postmenopause is the entire period of time that comes after the last menstrual period.

Menopause is the time in a woman's life when the function of the ovaries ceases. The ovary (female gonad), is one of a pair of reproductive glands in women. They are located in the pelvis, one on each side of the uterus. Each ovary is about the size and shape of an almond. The ovaries produce eggs (ova) and female hormones such as estrogen. During each monthly menstrual cycle, an egg is released f...

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Premarin

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OVERDOSE

Overdosage of estrogen may cause nausea, vomiting, breast tenderness, abdominal pain, drowsiness and fatigue and withdrawal bleeding may occur in women. Treatment of overdose consists of discontinuation of PREMARIN therapy with institution of appropriate symptomatic care.

CONTRAINDICATIONS

PREMARIN therapy should not be used in individuals with any of the following conditions:

  1. Undiagnosed abnormal genital bleeding.
  2. Known, suspected, or history of breast cancer except in appropriately selected patients being treated for metastatic disease.
  3. Known or suspected estrogen-dependent neoplasia.
  4. Active DVT, PE, or a history of these conditions.
  5. Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions.
  6. Known anaphylactic reaction or angioedema to PREMARIN tablets.
  7. Known liver dysfunction or disease.
  8. Known protein C, protein S, or antithrombin deficiency or other known thrombophilic disorders.
  9. Known or suspected pregnancy.

Last reviewed on RxList: 11/11/2011
This monograph has been modified to include the generic and brand name in many instances.

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