Premarin Injection
Premarin Injection Side Effects Center
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is Prescribing information?
The FDA package insert formatted in easy-to-find categories for health professionals and clinicians.
Premarin Injection FDA Prescribing Information: Side Effects
(Adverse Reactions)
SIDE EFFECTS
See BOXED WARNINGS, WARNINGS, and PRECAUTIONS.
Premarin Intravenous for injection is indicated for short-term use. However, the warnings, precautions and adverse reactions associated with oral Premarin treatment should be taken into account.
The following adverse reactions have been identified during post-approval use of oral or intravenous Premarin. Because these reactions are reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Genitourinary system
Abnormal uterine bleeding/spotting.
Dysmenorrhea or pelvic pain.
Increase in size of uterine leiomyomata.
Vaginitis, including vaginal candidiasis.
Change in amount of cervical secretion.
Change in cervical ectropion.
Ovarian cancer.
Endometrial hyperplasia.
Endometrial cancer.
Breasts
Tenderness, enlargement, pain, discharge, galactorrhea.
Fibrocystic breast changes.
Breast cancer.
Cardiovascular
Deep and superficial venous thrombosis.
Pulmonary embolism.
Thrombophlebitis.
Myocardial infarction.
Stroke.
Increase in blood pressure.
Gastrointestinal
Nausea, vomiting.
Abdominal cramps, bloating.
Cholestatic jaundice.
Increased incidence of gallbladder disease.
Pancreatitis.
Enlargement of hepatic hemangiomas.
Ischemic colitis.
Skin
Chloasma or melasma that may persist when drug is
discontinued.
Erythema multiforme.
Erythema nodosum.
Hemorrhagic eruption.
Loss of scalp hair.
Hirsutism.
Pruritis.
Rash.
Eyes
Retinal vascular thrombosis.
Intolerance to contact lenses.
Central Nervous System
Headache.
Migraine.
Dizziness.
Mental depression.
Exacerbation of chorea.
Nervousness.
Exacerbation of epilepsy.
Dementia.
Possible growth potentiation of benign meningioma.
Miscellaneous
Increase or decrease in weight.
Glucose intolerance.
Aggravation of porphyria.
Edema.
Arthralgia.
Leg cramps.
Changes in libido.
Urticaria.
Hypocalcemia (preexisting condition).
Injection site pain.
Injection site edema.
Phlebitis (injection site).
Exacerbation of asthma.
Increased triglycerides.
Read the entire FDA prescribing information for Premarin Injection (Conjugated Estrogens for Injection) »
Additional Premarin Injection Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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