In this Article

• What are vaginal conjugated estrogens (Premarin Vaginal Cream)?
• What are the possible side effects of vaginal conjugated estrogens (Premarin Vaginal Cream)?
• What is the most important information I should know about vaginal conjugated estrogens (Premarin Vaginal Cream)?
• What should I discuss with my healthcare provider before using vaginal conjugated estrogens (Premarin Vaginal Cream)?
• How should I use vaginal conjugated estrogens (Premarin Vaginal Cream)?
• What happens if I miss a dose (Premarin Vaginal Cream)?
• What happens if I overdose (Premarin Vaginal Cream)?
• What should I avoid while using vaginal conjugated estrogens (Premarin Vaginal Cream)?
• What other drugs will affect vaginal conjugated estrogens (Premarin Vaginal Cream)?
• Where can I get more information?

What happens if I miss a dose (Premarin Vaginal Cream)?

Use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and use your medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose (Premarin Vaginal Cream)?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, or vaginal bleeding.

What should I avoid while using vaginal conjugated estrogens (Premarin Vaginal Cream)?

Do not smoke while using this medication. Smoking can increase your risk of blood clots, stroke, or heart attack caused by vaginal conjugated estrogens.

What other drugs will affect vaginal conjugated estrogens (Premarin Vaginal Cream)?

Before using conjugated estrogens, tell your doctor if you are using any of the following medicines:

• a blood thinner such as warfarin (Coumadin);
• a thyroid medication such as levothyroxine (Synthroid);
• insulin or diabetes medicine taken by mouth;
• rifampin (Rifadin, Rifater, Rifamate, Rimactane);
• ketoconazole (Nizoral) or itraconazole (Sporanox);
• seizure medicines such as phenytoin (Dilantin), carbamazepine (Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), or primidone (Mysoline);
• a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton); or
• antidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil).

This list is not complete and there may be other drugs that can interact with vaginal conjugated estrogens. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about vaginal conjugated estrogens.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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