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Brand Names: Premarin Vaginal, Synthetic Conjugated Estrogens, A

Generic Name: conjugated estrogens (vaginal) (Pronunciation: KON joo gay ted ES troe jenz)

• What are vaginal conjugated estrogens (Premarin Vaginal Cream)?
• What are the possible side effects of vaginal conjugated estrogens (Premarin Vaginal Cream)?
• What is the most important information I should know about vaginal conjugated estrogens (Premarin Vaginal Cream)?
• What should I discuss with my healthcare provider before using vaginal conjugated estrogens (Premarin Vaginal Cream)?
• How should I use vaginal conjugated estrogens (Premarin Vaginal Cream)?
• What happens if I miss a dose (Premarin Vaginal Cream)?
• What happens if I overdose (Premarin Vaginal Cream)?
• What should I avoid while using vaginal conjugated estrogens (Premarin Vaginal Cream)?
• What other drugs will affect vaginal conjugated estrogens (Premarin Vaginal Cream)?
• Where can I get more information?

What are vaginal conjugated estrogens (Premarin Vaginal Cream)?

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Vaginal conjugated estrogens are a mixture of estrogen hormones used to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse.

Vaginal conjugated estrogens should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.

Vaginal conjugated estrogens may also be used for other purposes not listed in this medication guide.

What are the possible side effects of vaginal conjugated estrogens (Premarin Vaginal Cream)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

• chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
• sudden numbness or weakness, especially on one side of the body;
• sudden headache, confusion, problems with vision, speech, or balance;
• pain or swelling in your lower leg;
• abnormal vaginal bleeding;
• migraine headache;
• pain, swelling, or tenderness in your stomach;
• confusion, problems with memory or concentration;
• jaundice (yellowing of the skin or eyes);
• swelling in your hands, ankles, or feet; or
• a breast lump.

Less serious side effects may include:

• mild nausea, vomiting, bloating, stomach cramps;
• breast pain, tenderness, or swelling;
• freckles or darkening of facial skin;
• increased hair growth, loss of scalp hair;
• changes in weight or appetite;
• problems with contact lenses;
• vaginal itching or discharge;
• changes in your menstrual periods, decreased sex drive; or
• headache, nervousness, dizziness, tired feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about vaginal conjugated estrogens (Premarin Vaginal Cream)?

This medication can cause birth defects in an unborn baby. Do not use vaginal conjugated estrogens if you are pregnant.

Do not use this medication if you have any of the following conditions: a history of heart attack, stroke, or blood clot (especially in your lung or your lower body), liver disease, abnormal vaginal bleeding, or a hormone-related cancer such as breast or uterine cancer.

Long-term treatment with conjugated estrogens may increase your risk of breast cancer, heart attack, or stroke. Talk with your doctor about your individual risks before using vaginal conjugated estrogens long term, especially if you smoke or are overweight. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using vaginal conjugated estrogens.

Vaginal conjugated estrogens should not be used to prevent heart disease or dementia, because this medication may actually increase your risk of developing these conditions.