"March 14, 2013 -- Hormone replacement therapy is the most effective treatment for symptoms like hot flashes, and the benefits are likely to outweigh the risks, major medical societies say.
The statement was published in the April issue "...
Overdosage of estrogen plus progestin may cause nausea, vomiting, breast tenderness, abdominal pain, drowsiness and fatigue, and withdrawal bleeding may occur in women. Treatment of overdose consists of discontinuation of PREMPRO or PREMPHASE therapy with institution of appropriate symptomatic care.
PREMPRO or PREMPHASE therapy should not be used in women with any of the following conditions:
- Undiagnosed abnormal genital bleeding
- Known, suspected, or history of breast cancer
- Known or suspected estrogen-dependent neoplasia
- Active DVT, PE, or a history of these conditions
- Active arterial thromboembolic disease (for example, stroke and MI), or a history of these conditions
- Known anaphylactic reaction or angioedema to PREMPRO/PREMPHASE
- Known liver dysfunction or disease
- Known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders
- Known or suspected pregnancy
Last reviewed on RxList: 9/15/2015
Additional Prempro, Premphase Information
- Prempro, Premphase Drug Interactions Center: conj estrog-medroxyprogest ace oral
- Prempro, Premphase Side Effects Center
- Prempro, Premphase in detail including Side Effects and Drug Images
- Prempro, Premphase Overview including Precautions
- Prempro, Premphase FDA Approved Prescribing Information including Dosage
Prempro, Premphase - User Reviews
Prempro, Premphase User Reviews
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