"Taking a widely used antidepressant during the first trimester of pregnancy is associated with an increased risk for congenital and cardiac malformations, concludes a systematic review and meta-analysis by Canadian researchers.
(dinoprostone) Cervical Gel
For Endocervical Use
PREPIDIL Gel contains dinoprostone as the naturally occurring form of prostaglandin E2 (PGE2) and is designated chemically as (5Z, 11a, 13E, 15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1-oic acid. The molecular formula is C20H32O5 and the molecular weight is 352.5. Dinoprostone occurs as a white to off-white crystalline powder with a melting point within the range of 65° to 69°C. It is soluble in ethanol, in 25% ethanol in water, and in water to the extent of 130 mg/100 mL. The active constituent of PREPIDIL Gel is dinoprostone 0.5 mg/3 g (2.5 mL gel); other constituents are colloidal silicon dioxide NF (240 mg/3 g) and triacetin USP (2760 mg/3 g).
The structural formula is represented below:
What are the possible side effects of dinoprostone topical (Cervidil, Prepidil, Prostin E2)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if your contractions slow down or become uneven, or if you have:
- sudden vaginal bleeding;
- cough, wheezing, chest tightness, trouble breathing; or
- pale skin, blue colored lips.
After your baby is born, seek emergency medical attention if you have any signs of excessive bleeding, such...
Last reviewed on RxList: 2/26/2010
This monograph has been modified to include the generic and brand name in many instances.
Additional Prepidil Information
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