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Details with Side Effects
Overdosage with PREPIDIL (dinoprostone cervical gel) Gel may be expressed by uterine hypercontractility and uterine hypertonus. Because of the transient nature of PGE2-induced myometrial hyperstimulation, nonspecific, conservative management was found to be effective in the vast majority of the cases; i.e., maternal position change and administration of oxygen to the mother. β-adrenergic drugs may be used as a treatment of hyperstimulation following the administration of PGE2 for cervical ripening.
Endocervically administered PREPIDIL (dinoprostone cervical gel) Gel is not recommended for the following:
- Patients in whom oxytocic drugs are generally contraindicated or where
prolonged contractions of the uterus are considered inappropriate, such as:
- cases with a history of cesarean section or major uterine surgery
- cases in which cephalopelvic disproportion is present
- cases in which there is a history of difficult labor and/or traumatic delivery
- grand multiparae with six or more previous term pregnancies cases with non-vertex presentation
- cases with hyperactive or hypertonic uterine patterns
- cases of fetal distress where delivery is not imminent
- in obstetric emergencies where the benefit-to-risk ratio for either the fetus or the mother favors surgical intervention
- Patients with hypersensitivity to prostaglandins or constituents of the gel.
- Patients with placenta previa or unexplained vaginal bleeding during this pregnancy.
- Patients for whom vaginal delivery is not indicated, such as vasa previa or active herpes genitalia.
Last reviewed on RxList: 2/26/2010
This monograph has been modified to include the generic and brand name in many instances.
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