March 28, 2017
Recommended Topic Related To:


"In a drug safety communication issued today, the US Food and Drug Administration (FDA) says it is aware of recent reports "questioning" the safety of prescription and over-the-counter (OTC) pain medicines when used during pregnancy, but that it l"...





Overdosage with PREPIDIL (dinoprostone cervical gel) Gel may be expressed by uterine hypercontractility and uterine hypertonus. Because of the transient nature of PGE2-induced myometrial hyperstimulation, nonspecific, conservative management was found to be effective in the vast majority of the cases; i.e., maternal position change and administration of oxygen to the mother. β-adrenergic drugs may be used as a treatment of hyperstimulation following the administration of PGE2 for cervical ripening.


Endocervically administered PREPIDIL (dinoprostone cervical gel) Gel is not recommended for the following:

  1. Patients in whom oxytocic drugs are generally contraindicated or where prolonged contractions of the uterus are considered inappropriate, such as:
    • cases with a history of cesarean section or major uterine surgery
    • cases in which cephalopelvic disproportion is present
    • cases in which there is a history of difficult labor and/or traumatic delivery
    • grand multiparae with six or more previous term pregnancies cases with non-vertex presentation
    • cases with hyperactive or hypertonic uterine patterns
    • cases of fetal distress where delivery is not imminent
    • in obstetric emergencies where the benefit-to-risk ratio for either the fetus or the mother favors surgical intervention
  2. Patients with hypersensitivity to prostaglandins or constituents of the gel.
  3. Patients with placenta previa or unexplained vaginal bleeding during this pregnancy.
  4. Patients for whom vaginal delivery is not indicated, such as vasa previa or active herpes genitalia.
This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 2/26/2010


Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Parenting and Pregnancy

Get tips for baby and you.