August 28, 2015
Recommended Topic Related To:


"Troy Brown, RN
Medscape Medical News

Clostridium difficile caused nearly half a million infections and was associated with about 29,000 deaths in 2011, according to new data released today by the Centers for Disease Control "...


(sodium picosulfate, magnesium oxide, and anhydrous citric acid) for Oral Solution


PREPOPIK (sodium picosulfate, magnesium oxide and anhydrous citric acid) for oral solution is provided in two packets, the contents of each to be dissolved in 5 ounces of cold water and consumed.

Each packet contains 10 mg sodium picosulfate, 3.5 g magnesium oxide and 12 g anhydrous citric acid. The product also contains the following inactive ingredients, potassium hydrogen carbonate, saccharine sodium, and spray dried orange flavor which contains acacia gum, lactose, ascorbic acid and butylated hydroxyanisole. The following is a description of the three active ingredients:

Sodium picosulfate is a stimulant laxative.

Sodium picosulfate

  • Chemical name: 4,4´-(2-pyridylmethylene) diphenyl bis(hydrogen sulfate) disodium salt, monohydrate
  • Chemical formula: C18H13NNa2O8S2.H2O
  • Molecular weight: 499.4
  • Structural formula:

Sodium picosulfate Structural Formula Illustration

  • Sodium picosulfate

Magnesium citrate, which is formed in solution by the combination of magnesium oxide and anhydrous citric acid, is an osmotic laxative.

Magnesium oxide

  • Chemical name: Magnesium oxide
  • Chemical formula: Mg O
  • Molecular weight: 40.3
  • Structural formula: Mg O

Anhydrous citric acid

  • Chemical name: 2-hydroxypropane-1,2,3-tricarboxylic acid
  • Chemical formula: C6H8O7
  • Molecular weight: 192.1
  • Structural formula:

  (sodium picosulfate, magnesium oxide, and anhydrous citric acid) Structural Formula Illustration

Anhydrous citric acid

Last reviewed on RxList: 7/27/2012
This monograph has been modified to include the generic and brand name in many instances.

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

GI Disorders

Get the latest treatment options.