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home > drugs a-z list > prevacid i.v. (lansoprazole for injection) drug center > prevacid i.v. (lansoprazole for injection) drug - overdosage and contraindications
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Prevacid IV
Why does reflux laryngitis occur?
Reflux is caused by weakness in the muscle at the junction of the esophagus with the stomach. Normally, this muscular valve, or sphincter, functions to keep food and stomach acid from moving upward from the stomach to the esophagus and larynx. This valve opens to allow food into the stomach and closes to keep the stomach's contents from coming back up. The backward movement of stomach contents (gastric contents) up into the esophagus is referred to as gastroesophageal reflux.
Additionally, any increase in abdominal pressure (such as obesity), which can push acid back from the stomach up the esophagus, or a patient with a hiatal hernia, will have an increased risk for reflux. When it causes symptoms, it is referred to as gastroesophageal reflux disease (or GERD). When the acid backs up into the voice box (larynx), the condition is referred to as reflux laryngitis.
Stomach acid can cause irritati...
Prevacid I.V.
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OVERDOSE
Single intravenous doses of PREVACID at 218 mg/kg in mice (approximately 30 times the recommended human dose based on BSA) and 167 mg/kg in rats (approximately 46 times the recommended human dose based on BSA) were lethal. The symptoms of acute toxicity were decreased locomotor response, ataxia, ptosis and tonic convulsions.
PREVACID is not removed from the circulation by hemodialysis.
CONTRAINDICATIONS
PREVACID I.V. (lansoprazole for injection) for Injection is contraindicated in patients with known severe hypersensitivity to any component of the formulation.
Last reviewed on RxList: 7/11/2007
This monograph has been modified to include the generic and brand name in many instances.
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Additional Prevacid I.V. Information
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Prevacid I.V.
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