"The U.S. Food and Drug Administration today approved Tivicay (dolutegravir), a new drug to treat HIV-1 infection.
Tivicay is an integrase strand transfer inhibitor that interferes with one of the enzymes necessary for HIV to multiply. "...
Prezista Consumer (continued)
To help your doctor or pharmacist give you the best care, be sure to tell your doctor or pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.
Some of the products that may interact with this drug include: certain azole fungal medications (ketoconazole, itraconazole, voriconazole), boceprevir, efavirenz, pimozide, telaprevir.
Other medications can affect the removal of darunavir from your body, which may affect how darunavir works. Examples include certain anti-seizure drugs (carbamazepine, phenytoin, phenobarbital, primidone), dexamethasone, garlic supplements, rifamycins (such as rifabutin, rifampin, rifapentine), St. John's Wort, among others.
Darunavir can speed up or slow down the removal of other drugs from your body, which may affect how they work. Examples of affected drugs include antiarrhythmic drugs (such as amiodarone, lidocaine, quinidine), antidepressants (such as desipramine, paroxetine, sertraline, trazodone), artemether/lumefantrine, certain benzodiazepines (midazolam, triazolam), certain beta blockers (such as metoprolol, timolol), certain calcium channel blockers (such as nifedipine, felodipine, nicardipine), certain cancer drugs (sunitinib, lapatinib, dasatinib, temsirolimus), cisapride, digoxin, ergot alkaloids (such as dihydroergotamine, ergonovine, ergotamine, methylergonovine), drugs to treat erectile dysfunction/pulmonary hypertension (such as sildenafil, vardenafil), certain drugs that weaken the immune system (cyclosporine, sirolimus, tacrolimus), inhaled fluticasone, certain other HIV protease inhibitors (lopinavir, saquinavir), methadone, ranolazine, salmeterol, "statin" cholesterol drugs (such as lovastatin, simvastatin), warfarin, among others.
If any of these medications are taken with darunavir, your doctor may change your dose of darunavir or the other drug(s), or your doctor may monitor you specially. Consult your doctor or pharmacist for more details.
This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. However, to reduce the risk of spreading HIV to others, always use barrier protections during all sexual activity. (See also Notes section.)
This document does not contain all possible interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.
OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US National Poison Hotline at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: To reduce the risk of spreading HIV to others, always use effective barrier protections (such as latex or polyurethane condoms, dental dams) during all sexual activity. Consult your doctor or pharmacist for more details.
Do not share this medication with others.
Laboratory and/or medical tests (such as liver tests, viral load, T-cell counts, triglycerides/cholesterol, blood sugar) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.
Keep all medical and laboratory appointments.
MISSED DOSE: If you are taking this medication 2 times daily and you miss a dose, take it as soon as you remember unless it is less than 6 hours before the time for your next dose. If you are taking this medication once daily and you miss a dose, take it as soon as you remember unless it is less than 12 hours before the time for your next dose. In either case, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Do not refrigerate or freeze the liquid form of this medication. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-800-854-1166 (US) or 1-800-668-1507 (Canada).
Information last revised April 2012. Copyright(c) 2012 First Databank, Inc.
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